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IFNG — MUC1

Text-mined interactions from Literome

Karanikas et al., J Immunother 2001 (Adenocarcinoma...) : Cellular responses ( proliferation, cytotoxic T cells, or CD8 T cells secreting tumor necrosis factor-alpha alphand interferon-gamma in response to MUC1 stimulation in vitro ) were found in 28 % of the patients, which was similar to that seen without cyclophosphamide
Lagow et al., J Cell Biochem 2002 (Breast Neoplasms) : Synergistic stimulation of MUC1 expression in normal breast epithelia and breast cancer cells by interferon-gamma and tumor necrosis factor-alpha ... We demonstrate that MUC1 expression in T47D breast cancer cells and normal human mammary epithelial cells ( HMEC ) is enhanced by tumor necrosis factor-alpha (TNF-alpha) in the presence of interferon-gamma (IFN-gamma) ... Collectively, these studies demonstrate synergistic stimulation of MUC1 expression by TNF-alpha and IFN-gamma that is mediated by independent actions of NFkappaB p65 and STAT1alpha upon kappaB and STAT sites, respectively, in the MUC1 promoter
Reddy et al., Eur J Cancer 2003 (Neoplasms, Glandular and Epithelial) : Interferon-gamma upregulates MUC1 expression in haematopoietic and epithelial cancer cell lines, an effect associated with MUC1 mRNA induction ... Changes in MUC1 mRNA levels in response to IFN-gamma were assessed by semi-quantitative reverse transcriptase-polymerase chain reaction ( RT-PCR )
O'Connor et al., Prostate Cancer Prostatic Dis 2005 (Prostatic Neoplasms) : Furthermore, IFN-gamma and TNF-alpha strongly induce MUC1 expression in both normal prostate epithelia and certain prostate tumor cell lines and may exacerbate pathologies associated with MUC1 positive prostate cancers
Agrawal et al., Int Immunol 2005 : MUC1 expression on activated T cells was increased in the presence of IL-12 but was not affected by IFN-gamma , IL-2, IL-4, IL-5, IL-10, IL-13 or TNF-alpha
Gückel et al., J Cancer Res Clin Oncol 2006 (Breast Neoplasms...) : Those T-cells showed MUC-1 dependent IFN-gamma production after short-term stimulation but no clear Granzyme B expression
Wu et al., Am J Physiol Lung Cell Mol Physiol 2007 (Hypersensitivity...) : Furthermore, air-liquid interface cultures of mouse primary tracheal epithelial cells were performed to examine the effects of IFN-gamma on mucin expression ... In cultured mouse primary tracheal epithelial cells, IFN-gamma was shown to directly inhibit mucin expression in a dose dependent manner
Brayman et al., Mol Endocrinol 2007 (Breast Neoplasms) : We and others have shown that MUC1 expression is activated by progesterone ( P ), TNF-alpha, and interferon-gamma (IFN-gamma) ... In contrast, PIASy suppression of IFN-gamma activated MUC1 promoter activity was dependent on the PIASy sumoylation domain
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma , interleukin-4, or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Khodarev et al., Oncogene 2010 (Breast Neoplasms) : The interaction between MUC1-C and STAT1 is inducible by IFNgamma in non-malignant epithelial cells and constitutive in breast cancer cells
Kim et al., J Immunol 2010 : T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production
Hashimoto et al., Hokkaido Igaku Zasshi 1988 (Lung Neoplasms) : While the culture supernatants of non stimulated PEM from MRL mice had no IL-1 and TNF activity, those of recombinant IFN-gamma stimulated PEM from lpr/lpr mice had higher IL-1 and TNE activity than those from +/+ mice
Fidler et al., J Immunol 1985 : The activation of human monocytes or mouse PEM by free unencapsulated r-IFN-gamma and MDP was species specific : human r-IFN-gamma activated human blood monocytes to lyse allogeneic melanoma cells, but did not activate mouse PEM ... Mouse r-IFN-gamma activated mouse PEM to lyse syngeneic melanoma cells, but did not activate cytotoxic properties in human monocytes
Jarry et al., Eur J Pharmacol 1994 : The aim of the present study was ( 1 ) to investigate the regulatory effects of interferon-gamma on baseline and stimulated mucin secretion elicited by an increase in intracellular cAMP, either a short-term increase ( induced by vasoactive intestinal peptide or by forskolin ) or a long-term increase ( cholera toxin induced ), and ( 2 ) to attempt to delineate the site of action of interferon-gamma ... We thus concluded that the target for interferon-gamma inhibition of cAMP stimulated Cl.16E mucin secretion is distal to protein kinase A and might be a component of the exocytotic machinery
Clark et al., Dis Markers 1994 (Ovarian Neoplasms) : Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian carcinoma cell lines ... Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian carcinoma cell lines