Servant et al., J Cell Biol 2000
:
Importantly, the repression of p27 ( Kip1 ) synthesis by PDGF-BB was associated with a marked attenuation of Kip1 gene transcription and a corresponding decrease in Kip1 mRNA accumulation
Zhan et al., Arterioscler Thromb Vasc Biol 2002
:
Ad-DN-c-Jun attenuated PDGF-BB induced downregulation of p27 ( Kip1 ), as shown by Western blot analysis, and the prevented PDGF-BB induced decrease in cyclin E/cyclin dependent kinase 2 complex associated p27 ( Kip1 ), as shown by immunoprecipitation study
Nathe et al., Arterioscler Thromb Vasc Biol 2002
(Arteriosclerosis) :
Our data suggest that IL-1beta may promote SMC proliferation after vascular injury and in atherogenesis by suppression of PDGF-BB induced p21 and p27 Sakakibara et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
To delineate the molecular mechanism underlying the p27 down-regulation, we examined the effect of PDGF-BB on p27 promoter activity as well as mRNA stability