Gene interactions and pathways from curated databases and text-mining

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PAK4 — TNF

Text-mined interactions from Literome

Park et al., Am J Physiol Lung Cell Mol Physiol 2012 : These combined data are consistent with the hypothesis that PPAR? stimulates MUC1/Muc1 expression, thereby blocking PMA/PAK induced TNF-a/IL-8 production by airway epithelial cells
Kim et al., J Clin Endocrinol Metab 2013 (Endometriosis...) : TNF-a induced a significant increase in the Pak4 expression in endometrial cells in vitro, whereas IL-1ß had no effects ... These findings suggest that Pak4 is regulated by progesterone and TNF-a in endometrial cells and that the increased expression of Pak4 might lead to the establishment and progression of endometriosis by enhanced cellular viability and invasiveness in endometrial cells