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CDKN1A — EGFR

Text-mined interactions from Literome

Reddy et al., Int J Oncol 1999 : These results suggest that the level of EGFR tyrosine kinase activity may regulate p21/WAF1 induction in cancer cells
Donato et al., Clin Cancer Res 2000 (Uterine Cervical Neoplasms) : Activation of EGFr in Pt-R cells stimulated cell cycle progression ( 2-fold ), reduced p21WAF1 levels ( > 2-fold ), and increased sensitivity to cDDP ( 3-fold ), suggesting that receptor signaling enhanced the efficacy of cDDP to induce cell death by relieving cell cycle restriction
Huang et al., J Biomed Sci 2006 (Carcinoma, Squamous Cell) : The As2O3 induced p21 activation was attenuated by inhibitors of EGFR and MEK in a dose dependent manner
Serth et al., Biochemistry 1992 : Binding of the H-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro
Pu et al., Biochem Pharmacol 2006 (Adenocarcinoma...) : These molecular events were accompanied by Bad up-regulation, p53 and p21Waf1/Cip1 induction, ERK1/2 inactivation and inhibition of EGFR phosphorylation in the presence of PD168393
Santra et al., J Cereb Blood Flow Metab 2006 (Glioma) : Blocking of phosphoinositide 3-kinase (PI-3K), Ras, and the epidermal growth factor receptor with specific inhibitors had no effect on induction of Ras, p21 , and p27 at the messenger RNA level in decorin synthesizing SVZ and U-87 cells
Sheng et al., Gastroenterology 2006 (Colonic Neoplasms) : This study sought to establish a mechanistic link between EGFR mediated intestinal epithelial cell proliferation and p21 ( waf1/cip1 ) expression ... EGFR mediated induction of enterocyte proliferation requires MAPK dependent increase in p21 ( waf1/cip1 ) expression in intestinal epithelial cells
Lee et al., American journal of physiology. Renal physiology 2008 : Consequently, the inhibition of Ca ( 2+ ), PKC, EGFR , p44/42 MAPKs, or NF-kappaB blocked the BSA induced increases in cyclin D1, cyclin dependent kinase (CDK)4, cyclin E, or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression
Cao et al., Am J Respir Cell Mol Biol 2010 : Using chromatin immunoprecipitation assays and expression of a dominant negative Stat3 mutant, we show that activation of Stat3 and its binding to the p21 promoter are required for DEP induced expression of p21, suggesting that Stat3 plays an essential role in the induction of p21 by DEP. Additional experiments demonstrated that activation of p21 gene expression is dependent on the activation of epidermal growth factor receptor and Src kinase activities
Deb et al., Am J Physiol Cell Physiol 2011 : Collectively, these data suggest that 1 ) Pnck induces ligand independent EGFR degradation most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation, 2 ) EGFR degradation is coupled to proteasomal degradation of Pnck, and 3 ) modulation of basal MAP kinase activity, p21/Cip-1/Waf-1 expression, and cellular growth by Pnck is independent of Pnck induced ligand independent EGFR degradation
Ravikumar et al., J Surg Res 1989 (Colonic Neoplasms) : The expression of various epitopes of epidermal growth factor receptor (EGFr) and mutational activations of ras gene product p21 in colorectal primary cancers from 16 patients have been analyzed in this study
Skarpen et al., Exp Cell Res 1998 : Consistently, we found more rapid dephosphorylation of the EGFR and less induction of p21/CIP1 by TGFalpha than by EGF ... When surface bound TGFalpha was removed by acid stripping and endosomal pH was neutralized with bafilomycin A1, TGFalpha stimulated EGFR tyrosine phosphorylation, induced p21/CIP1 , and inhibited DNA synthesis ... This strongly suggests that p21/CIP1 can be induced by endocytosed, activated EGFR and that endocytosed EGFR can affect cell growth