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EPHB2 — TRPC6
Text-mined interactions from Literome
Zhang et al., Experimental biology and medicine (Maywood, N.J.) 2009
:
TRPC6 up-regulation in Ang II-induced podocyte apoptosis might
result from
ERK activation and NF-kappaB translocation
Li et al., Am J Respir Cell Mol Biol 2013
(Calcium Signaling...) :
Real-time quantitative PCR was used for the measurement of mRNA, Western blotting was used for the measurement of protein, and fluorescent microscopic for [ Ca ( 2+ ) ] i was used to determine the
involvement of p38 and
extracellular regulated kinase (ERK)-1/2 mitogen activated protein kinase ( MAPK ) signaling in BMP4 induced
TRPC expression and the elevation of [ Ca ( 2+ ) ] i in PASMCs
Chiluiza et al., J Biol Chem 2013
(Glomerulosclerosis, Focal Segmental) :
In 293T cells and cultured podocytes, overexpression of gain-of-function
TRPC6 mutants
resulted in increased
ERK1/2 phosphorylation, an effect dependent upon channel function ... Phosphorylation of Thr-70, Ser-282, and Tyr-31/285 were not necessary for
ERK activation by mutant
TRPC6 , although a phosphomimetic TRPC6 S282E mutant was capable of ERK activation