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The FcgammaRIIB blockade inhibits GXM induced IL-10 production and induces TNF-alpha secretion
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PRRSV infection assay mediated by Fc?RIIB indicated that selective activation of porcine Fc?RIIB in PAM cells enhanced mRNA levels of antiviral cytokine ( IFN-a and TNF-a ) and repressed mRNA levels of IL-10 in response to PRRSV infection, suggesting that Fc?RIIB ligation can enhance the antiviral immune response to PRRSV infection
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IL-13 induced up-regulation of class II MHC Ag and its down-regulatory effects on CD64, CD32 , and CD16 expression were prevented by IL-10