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Yeo et al., J Biol Chem 2003
:
In contrast, overexpression of DN-IRAK1 or DN-TRAF6 only partially inhibited CpG DNA induced Cox-2 promoter activity and NF-kappaB activation, indicating the presence of additional signaling modulators downstream of MyD88
Kim et al., Cell Physiol Biochem 2012
(MAP Kinase Signaling System) :
The downregulation of IRAK1 inhibited TNF-a induced NF-?B activation and COX-2 expression