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CD86 — DPP4

Text-mined interactions from Literome

Ohnuma et al., J Immunol 2001 : Soluble CD26/dipeptidyl peptidase IV induces T cell proliferation through CD86 up-regulation on APCs
Ohnuma et al., Proc Natl Acad Sci U S A 2004 : Finally, reduced caveolin-1 expression on monocytes inhibits CD26 mediated CD86 up-regulation and abrogates CD26 effect on TT-induced T cell proliferation ... Taken together, these results strongly suggest that CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation
Ohnuma et al., Mol Cell Biol 2005 : CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen presenting cells
Ohnuma et al., Mod Rheumatol 2006 (Arthritis, Rheumatoid...) : Finally, reduced caveolin-1 expression on APC inhibits CD26 mediated CD86 upregulation and abrogates CD26 effect on TT-induced T-cell proliferation, and immunohistochemical studies revealed an infiltration of CD26+ T cells in the sub lining region of rheumatoid synovium and high expression of caveolin-1 in the increased vasculature and synoviocytes of the rheumatoid synovium ... Taken together, these results strongly suggest that CD26-cavolin-1 interaction plays a role in the upregulation of CD86 on TT-loaded APC and subsequent engagement with CD28 on T cells, leading to antigen-specific T-cell activation such as the T-cell mediated antigen-specific response in rheumatoid arthritis