Gene interactions and pathways from curated databases and text-mining

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ALK — PI3

Text-mined interactions from Literome

Slupianek et al., Cancer Res 2001 (Cell Transformation, Neoplastic...) : Our studies showed that NPM/ALK , similar to other members of this family, activates phosphatidylinositol 3-kinase (PI3K) and its downstream effector, serine/threonine kinase ( Akt )
Vega et al., Cancer Res 2006 (Lymphoma, Large B-Cell, Diffuse) : Previously, nucleophosmin-ALK has been shown to activate phosphatidylinositol 3-kinase (PI3K) and its downstream effector, the serine/threonine kinase AKT