Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Veenstra et al., J Immunol 2002 (Neoplasms) : In contrast, IL-1alpha, IL-1beta, TNF-alpha , IFN-gamma-inducible protein-10, and Th2 cytokines such as IL-4 and IL-10 did not induce IL-18BPa
Kim et al., Cancer Lett 2003 : In this study, we investigated the effects of BPA on the production of nitric oxide ( NO ) and tumor necrosis factor-alpha (TNF-alpha) , and on the level of inducible nitric oxide synthase (iNOS) and TNF-alpha gene expression in mouse macrophages ... BPA alone did not affect NO or TNF-alpha production ... In contrast, BPA inhibited lipopolysaccharide (LPS) induced NO and TNF-alpha production, and the levels of iNOS and TNF-alpha mRNA in a dose dependent manner
Benachour et al., Toxicol Appl Pharmacol 2009 : We also showed that BPA increased significantly the tumor-necrosis factor alpha (TNF-alpha) gene expression and protein excretion as measured by real-time RT-PCR and ELISA luminescent test, respectively ... Moreover, we observed that induction of AK activation and TNF-alpha gene expression require lower levels of BPA than apoptosis or TNF-alpha protein excretion
Marotte et al., Arthritis Rheum 2010 (Arthritis, Rheumatoid...) : Evaluation of signaling pathways suggested that TNFalpha induced IL-18 production through the ERK-1/2, protein kinase Cdelta (PKCdelta), and Src pathways, whereas IL-18BPa synthesis was mediated through the NFkappaB, PKC, Src, and JNK pathways
Byun et al., Environ Toxicol Pharmacol 2005 : We investigated the effects of BPA exposure on the activities of murine peritoneal macrophages through evaluation of BPA induced alteration of nitric oxide ( NO ) production, tumor necrosis factor-a (TNF-a) synthesis, and expression of co-stimulatory molecules B7 ... In vitro, BPA suppressed TNF-a secretion with significant reduction at 10 and 100µM BPA