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CSF3 — GFI1

Text-mined interactions from Literome

Zhuang et al., J Biol Chem 2006 (Neutropenia) : Truncation of the carboxyl terminus of the G-CSF receptor, as seen in patients with acute myeloid leukemia evolving from severe congenital neutropenia, disrupted Gfi-1 up-regulation by G-CSF
De La Luz Sierra et al., Blood 2007 : We show that in vitro and in vivo G-CSF promotes expression of Gfi-1 and down-regulates expression of CXCR4, a chemokine receptor essential for the retention of hematopoietic stem cells and granulocytic cells in the bone marrow
de la Luz Sierra et al., Blood 2010 : The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1 ... We report that Gfi1 promotes the expression of Ras guanine nucleotide releasing protein 1 ( RasGRP1 ), an exchange factor that activates Ras, and that RasGRP1 is required for G-CSF signaling through the Ras/mitogen activated protein/extracellular signal regulated kinase ( MEK/Erk ) pathway