Gene interactions and pathways from curated databases and text-mining

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IRF2 — RELA

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Chae et al., Biochem Biophys Res Commun 2008 : IRF-2 regulates NF-kappaB activity by modulating the subcellular localization of NF-kappaB ... While the nuclear recruitment of RelA by IRF-2 augments TNFalpha induced NF-kappaB dependent transcription, the N-terminal truncated mutant form of IRF-2 inhibits the nuclear localization of RelA , and thus interferes with NF-kappaB activation ... Thus, these results show that IRF-2 regulates NF-kappaB activity via the modulation of NF-kappaB subcellular localization
Drew et al., J Neuroimmunol 1995 (Neuroblastoma) : Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells
Cheng et al., J Interferon Cytokine Res 1998 : Therefore, effective ISRE activity of IP-10 VRE may require an IRF-like protein binding, which is enhanced by an NF-kappaB heterodimer binding to an adjacent KB site