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Granet et al., Cell Signal 2002
:
Downregulation of protein kinase C ( PKC ) and
COX1/2 or inhibition of ERK1/2, p38 ( MAPK ) or src kinases
had no major effect on
AP-1 mRNA expression in the Flexcell
Tomita et al., Respirology 2002
:
Using a human airway cell line ( LC-2/ad ), lipopolysaccharide (LPS) induced gene expression of hBD-2 was studied in the absence or the presence of ( i ) dexamethasone, ( ii )
inhibition of NF-kappaB and
AP-1 , ( iii ) intracellular calcium chelator, and ( iv )
cyclooxygenase (COX) inhibitors ... These findings suggest that glucocorticoids ( GC ), but not
COX inhibitors,
reduce hBD-2 gene expression, while NF-kappaB,
AP-1 and intracellular calcium are essential for hBD-2 expression
Liu et al., J Biol Chem 2003
(Cell Transformation, Neoplastic) :
However, in the present study we found that both piroxicam, a general
COX inhibitor, and NS-398, a COX-2 selective inhibitor, effectively
suppressed the activation of transcription factor
activator protein 1 (AP-1) induced by ultraviolet B ( UVB ) or 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal JB6 cells
Hwang et al., J Biol Chem 2005
:
Here, we investigated the
role of c-Jun and
activator protein-1 (AP-1) in IL-1beta induced dedifferentiation and
cyclooxygenase (COX)-2 expression in primary cultured chondrocytes ... Here, we investigated the
role of
c-Jun and activator protein-1 (AP-1) in IL-1beta induced dedifferentiation and
cyclooxygenase (COX)-2 expression in primary cultured chondrocytes
Uenoyama et al., Oncogene 2006
(Anoxia...) :
Furthermore,
COX-2 expression was also
reduced by the inhibition of transcription factor
AP-1
Lee et al., J Biomed Sci 2008
(Colitis...) :
In addition, consumption of UDN glycoprotein attenuated the activities of proliferating cell nuclear antigen ( PCNA ), inducible nitric oxide synthase (iNOS), and
cyclooxygenase-2 (COX-2) , and
inhibited the DNA binding activities of nuclear factor-kappa B (NF-kappaB) and
activator protein-1 (AP-1) in the mice colonic tissue