Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Granet et al., Cell Signal 2002 : Downregulation of protein kinase C ( PKC ) and COX1/2 or inhibition of ERK1/2, p38 ( MAPK ) or src kinases had no major effect on AP-1 mRNA expression in the Flexcell
Tomita et al., Respirology 2002 : Using a human airway cell line ( LC-2/ad ), lipopolysaccharide (LPS) induced gene expression of hBD-2 was studied in the absence or the presence of ( i ) dexamethasone, ( ii ) inhibition of NF-kappaB and AP-1 , ( iii ) intracellular calcium chelator, and ( iv ) cyclooxygenase (COX) inhibitors ... These findings suggest that glucocorticoids ( GC ), but not COX inhibitors, reduce hBD-2 gene expression, while NF-kappaB, AP-1 and intracellular calcium are essential for hBD-2 expression
Liu et al., J Biol Chem 2003 (Cell Transformation, Neoplastic) : However, in the present study we found that both piroxicam, a general COX inhibitor, and NS-398, a COX-2 selective inhibitor, effectively suppressed the activation of transcription factor activator protein 1 (AP-1) induced by ultraviolet B ( UVB ) or 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal JB6 cells
Hwang et al., J Biol Chem 2005 : Here, we investigated the role of c-Jun and activator protein-1 (AP-1) in IL-1beta induced dedifferentiation and cyclooxygenase (COX)-2 expression in primary cultured chondrocytes ... Here, we investigated the role of c-Jun and activator protein-1 (AP-1) in IL-1beta induced dedifferentiation and cyclooxygenase (COX)-2 expression in primary cultured chondrocytes
Uenoyama et al., Oncogene 2006 (Anoxia...) : Furthermore, COX-2 expression was also reduced by the inhibition of transcription factor AP-1
Lee et al., J Biomed Sci 2008 (Colitis...) : In addition, consumption of UDN glycoprotein attenuated the activities of proliferating cell nuclear antigen ( PCNA ), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) , and inhibited the DNA binding activities of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in the mice colonic tissue