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McGough et al., J Neurosci 2004
(Alcoholism) :
We found that decreasing the levels of BDNF leads to increased behavioral responses to ethanol, whereas increases in the levels of BDNF , mediated by the scaffolding protein RACK1 , attenuate these behaviors
Neasta et al., J Biol Chem 2012
:
We further showed that nuclear RACK1 is required to promote the transcription of the brain derived neurotrophic factor (BDNF) ... We further observed that the disruption of RACK1/14-3-3? interaction with a peptide derived from the RACK1/14-3-3? binding site or shRNA mediated 14-3-3? knockdown inhibited cAMP induction of BDNF transcription