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IL13 — IL4R
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Dip Interaction:
IL4R
—
IL13
(physical association, biochemical)
Obiri et al., J Biol Chem 1995
-
IRef Hprd Interaction:
IL13
—
IL4R
(in vivo)
Howard et al., Am J Hum Genet 2002*
-
IRef Intact Interaction:
Complex of 13 proteins
(direct interaction, x-ray crystallography)
LaPorte et al., Cell 2008*
-
MIPS Negatome - no physical interaction between proteins Interaction:
IL4R
—
IL13
(Absence of interaction, affinity chromatography technologies)
Zurawski et al., J Biol Chem 1995*
-
MIPS Negatome - no physical interaction between proteins Interaction:
IL4R
—
IL13
(Absence of interaction, text mining, MI:0405)
Zurawski et al., Immunol Today 1994*
-
IRef Ophid Interaction:
IL4R
—
IL13
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Frost et al., Bone 2001
:
However, the antibodies did not affect the IL-4/-13 induced inhibition of [ ( 3 ) H ] -thymidine incorporation or the stimulation of alkaline phosphatase (ALP), suggesting that
IL-4Ralpha does not
mediate these effects of
IL-4/-13 in hOBs
Hirst et al., Am J Respir Crit Care Med 2002
:
Activation of
IL-4Ralpha by
IL-13 or IL-4 induced signal transducer and activation of transcription-6 ( STAT6 ), p42/ p44 ERK, p38, and to a lesser extent, SAPK/JNK mitogen activated protein kinase phosphorylation
Madden et al., J Immunol 2002
:
Binding of IL-4 by either the type 1 or 2 IL-4R, or of
IL-13 by the type 2 IL-4R,
initiates Jak dependent tyrosine phosphorylation of the
IL-4Ralpha-chain and the transcription factor, STAT6
Finkelman et al., J Immunol 2005
(Bronchial Hyperreactivity) :
Although IL-4 signals through two receptors, IL-4R alpha/common gamma-chain ( gamma(c) ) and
IL-4R alpha/IL-13R alpha1, and only the latter is also
activated by
IL-13 , IL-13 contributes more than IL-4 to goblet cell hyperplasia and airway hyperresponsiveness in murine asthma
Padilla et al., J Immunol 2005
:
Conversely,
IL-13 given by inhalation to naive mice increased the expression of MHC II and costimulatory molecules by CD11c ( high ) cells in an
IL-4Ralpha dependent manner
Andrews et al., J Immunol 2006
:
These data demonstrate that
IL-4Ralpha plays a key role in the binding affinity of both
IL-13R and IL-4R complexes
Webb et al., J Immunol 2007
(Asthma...) :
Because
IL-4Ralpha is
critical for IL-4 and
IL-13 signaling, we also determined how variants of IL-4Ralpha influenced immune cell function
Kasaian et al., Biochem Pharmacol 2008
(Asthma...) :
On B cells, monocytes, epithelial cells, and smooth muscle cells,
IL-13 acts through the
IL-13Ralpha1/IL-4Ralpha complex to directly induce activation responses that contribute to atopic disease
Barner et al., Curr Biol 1998
(Strongylida Infections) :
Our results suggest that
IL-13 regulates Th2 responses to nematode infection and
requires IL-4R alpha