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HIPK1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HIPK1 — TP53 (direct interaction, two hybrid) Kondo et al., Proc Natl Acad Sci U S A 2003*
• IRef Biogrid Interaction: HIPK1 — TP53 (physical association, affinity chromatography technology) Kondo et al., Proc Natl Acad Sci U S A 2003*
• IRef Hprd Interaction: TP53 — HIPK1 (two hybrid) Kondo et al., Proc Natl Acad Sci U S A 2003*
• IRef Hprd Interaction: TP53 — HIPK1 (in vivo) Kondo et al., Proc Natl Acad Sci U S A 2003*
• IRef Hprd Interaction: TP53 — HIPK1 (in vitro) Kondo et al., Proc Natl Acad Sci U S A 2003*
• IRef Intact Interaction: HIPK1 — TP53 (physical association, two hybrid) Kondo et al., Proc Natl Acad Sci U S A 2003*
• IRef Intact Interaction: HIPK1 — TP53 (physical association, anti bait coimmunoprecipitation) Kondo et al., Proc Natl Acad Sci U S A 2003*
• IRef Ophid Interaction: HIPK1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., BMC molecular biology 2001 : Instead, HIPK2 leads to a downregulation of p53 induced Mdm2 protein and this may lead to stabilization of p53
Guerra et al., PloS one 2012 : The HIPKs have been shown to be involved in growth regulation and apoptosis, with numerous studies highlighting HIPK regulation of the tumor suppressor p53