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IL6 — TIMP1

Text-mined interactions from Literome

Kossakowska et al., Blood 1999 (Lymphoma, Non-Hodgkin...) : Moreover, in human lymphoid cell lines of B- and T-cell origin ( Raji, Jurkat, and NC-37 ), IL-6 stimulated production of MMP-9 and MMP-2 but not TIMP-1
Seitz et al., Rheumatology (Oxford) 2000 (Arthritis, Rheumatoid) : Moreover, PBMNC of healthy donors revealed that MTX also stimulated TIMP-1 and IL-6 release in vitro, IL-6 being partially responsible for the induction of TIMP-1 production
Irwin et al., J Periodontol 2002 (Periodontal Diseases) : IL-6 and sIL-6r, either alone or in combination, had no marked effect on TIMP expression or cell growth
Sanchez et al., Biochem Pharmacol 2003 : IL-1beta increased IL-6 , IL-8, MIP-1beta, NO, PGE ( 2 ) and MMP-3 productions, but inhibited AGG and TIMP-1 synthesis
Dasu et al., Burns Incl Therm Inj 2003 : MMP-1 and TIMP-1 mRNA expression were markedly increased with IL-6 and TNF-alpha treatment and remains unchanged with IL-1beta
Kordula et al., FEBS Lett 1992 (Carcinoma, Hepatocellular...) : We show at mRNA and protein levels that TIMP-1 is expressed in differentiated human hepatoma cells ( HepG2 ) and that its synthesis is up-regulated by interleukin-6 (IL-6) , transforming growth factor beta 1 and phorbol 12-myristate 13-acetate
Kralisch et al., FEBS Lett 2005 : Interestingly, TNFalpha and IL-6 induced TIMP-1 protein secretion more than 3- and 2-fold, respectively ... Moreover, the thiazolidinedione troglitazone partly reversed TNFalpha- but not IL-6 induced TIMP-1 synthesis
Nieto et al., Hepatology 2006 : MMP13, a protease that degrades extracellular collagen I, decreased in the cocultures, while TIMP1 , a MMP13 inhibitor, increased ; and these effects were prevented by catalase, anti-IL-6 , and siRNA-IL-6
Guo et al., Braz J Med Biol Res 2007 (Carcinoma, Hepatocellular...) : Further studies indicated that TIMP-1 mediated the inhibitory effect of IL-6 on BEL-7402 cell proliferation in a STAT3 dependent manner, which could further accelerate the expression of the cyclin dependent kinase inhibitor p21 ... A dominant negative STAT3 mutant totally abolished IL-6 induced TIMP-1 expression and its biological functions
Lotz et al., J Biol Chem 1991 : Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity ( TIMP-1/EPA )
Sato et al., Biochem Biophys Res Commun 1990 : IL-6 did not modulate the expression of MMPs by these fibroblasts, but the production of TIMP was enhanced by IL-6 in a dose dependent manner, whereas IL-1 stimulated the production of both MMPs and TIMP
Pini et al., J Leukoc Biol 2012 (Inflammation...) : In DIO mice, production of OPN and TIMP-1 was increased for a prolonged period, and this was mediated by IL-6 in the liver but not the pancreas
Roeb et al., FEBS Lett 1994 (Acute-Phase Reaction) : TIMP-1 protein expression is stimulated by IL-1 beta and IL-6 in primary rat hepatocytes ... In primary rat hepatocytes we show for the first time that TIMP-1 protein expression is up-regulated upon stimulation with IL-1 beta and IL-6
Günther et al., Arthritis Rheum 1994 : To investigate the role of interleukin-6 (IL-6) and transforming growth factor beta 1 ( TGF beta 1 ) in the regulation of tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) synthesis in human articular chondrocytes ... In contrast to the findings in a previous study, IL-6 did not stimulate TIMP-1 expression in these cells, whereas TGF beta 1 was an important inducer of TIMP-1 mRNA and protein synthesis
Shingu et al., Clin Exp Immunol 1993 : In addition, tumour necrosis factor-alpha (TNF-alpha) significantly inhibited and IL-6 significantly enhanced TIMP production in endothelial cells, synovial cells and chondrocytes
Gatsios et al., Eur J Biochem 1996 : Interleukin-6 itself had no effect on synovial lining cells but a complex of interleukin-6 and the soluble interleukin-6 receptor induced activation of signal transducer and activator of transcription ( STAT ) factors in these cells and regulated TIMP-1 and TIMP-3 expression in a similar fashion as oncostatin M
Franchimont et al., J Biol Chem 1997 : IL-6 and IL-6sR enhanced the expression of tissue inhibitor of metalloproteinases 1
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments
Silacci et al., J Biol Chem 1998 : TIMP-1 production by isolated human articular synovial fibroblasts and chondrocytes, stimulated by IL-6 and/or its soluble receptor, was first assayed by specific enzyme linked immunosorbent assay ; the slight stimulatory effect of IL-6 on TIMP-1 production by both types of cells was markedly amplified by the addition of soluble receptor, the maximal secretion being observed only at 96 h. TIMP-1 mRNA expression, determined by ribonuclease protection assay, was induced by IL-6 together with its soluble receptor, but TIMP-2 and -3 mRNAs were not affected by these factors