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GPX4 — RELA

Text-mined interactions from Literome

Brigelius-Flohé et al., Atherosclerosis 2000 : Overexpression of PHGPx inhibits hydroperoxide induced oxidation, NFkappaB activation and apoptosis and affects oxLDL mediated proliferation of rabbit aortic smooth muscle cells
Zhou et al., Free Radic Biol Med 2001 : To test whether NF kappa B or AP-1 might be mediating the induction of GPx and CAT in muscle cells subjected to oxidative stress, we first characterized their activation by pro-oxidants ... In summary, our results suggest that NF kappa B and AP-1 are important mediators of redox-responsive gene expression in skeletal muscle, and that at least NF kappa B is actively involved in the upregulation of the GPx and CAT in response to oxidative stress
Viña et al., Biol Chem 2008 : Activation of NF-kappa B by estrogens subsequently activates the expression of Mn-SOD and GPx , but genistein is only capable of activating Mn-SOD expression
Kretz-Remy et al., J Cell Biol 1996 : Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression
Brigelius-Flohé et al., Biochem J 1997 : These results show that overexpressed PHGPx is sufficient to inhibit NF kappa B activation, and suggests that NF kappa B activation by IL-1 is mediated by a preferential substrate of PHGPx, such as a fatty acid hydroperoxide, rather than by H2O2, the preferred substrate of the more abundant cytosolic GPx