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EPHB2 — IL1A

Text-mined interactions from Literome

Miyazaki et al., J Cell Biol 2000 : Interleukin 1alpha (IL-1alpha) strongly induced ERK activation as well as NF-kappaB activation
Surapisitchat et al., Proc Natl Acad Sci U S A 2001 (MAP Kinase Signaling System) : TNF-alpha or IL-1 alone activated ERK1/2 , p38, and JNK maximally at 15 min in HUVEC
Rabehi et al., Infect Immun 2001 : When cells were stimulated by SAC, inhibition of the p38 pathway did not affect cytokine production, whereas only IL-1alpha production was decreased in the presence of ERK kinase inhibitor
Houliston et al., Am J Physiol Cell Physiol 2001 (MAP Kinase Signaling System) : The mitogen activated protein kinase ( MAPK ) kinase ( MEK ) inhibitors, PD-98059 and U-0126, blocked IL-1 alpha induced ERK activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release, suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation
Lee et al., J Biochem 2002 : PD98059, a specific inhibitor of the ERK activating kinase MEK1, also abolished the effects of IL-1alpha on ERK activation and osteoclast survival
Liacini et al., Matrix Biol 2002 (Osteoarthritis, Hip) : IL-1 rapidly induced the activation of extracellular-signal regulated kinase ( ERK ), protein 38 (p38) and c-Jun N-terminal kinase (JNK) MAPKs in the first-passage human femoral head OA chondrocytes
Skifter et al., Metab Brain Dis 2002 (Brain Ischemia...) : Previous studies using various stimuli have shown ERK dependent IL-1 induction
Kim et al., Mol Pharmacol 2002 : These results indicate that in human pulmonary epithelial cells, IL-1beta activates ERK or p38 to induce COX-2 production, which in turn induces MUC2 and MUC5AC production
Pinteaux et al., J Neurochem 2002 : In comparison, IL-1beta induced the release of PGE2, IL-6 and activated NF-kappaB, p38, JNK and ERK1/2 in mixed glial cultures, but failed to induce any of these responses in microglial cell cultures
Maggi et al., J Biol Chem 2003 (Cardiovirus Infections...) : Inhibitors of ERK activation prevent dsRNA induced ERK phosphorylation and IL-1 expression by macrophages
Li et al., Arthritis Rheum 2003 : In chondrocyte monolayers, both basal and IL-1 stimulated ERK activities were similarly elevated at 0.5 hours after medium change, diminishing by 74 % after 16 hours ... In contrast, chondrocytes in other culture configurations exhibited lower basal levels of ERK activity and a moderate activation of ERK in response to IL-1 that was sustained over the 16-hour treatment time ... ERK signaling in response to IL-1 in chondrocyte monolayers exhibited a pattern that was distinct from that in other culture systems, suggesting that the extracellular matrix plays an important regulatory role in modulating the response to extracellular stimuli
Hobbs et al., J Biol Chem 2003 (Dermatitis) : We investigated the link between aberrant integrin expression, Erk activation , and expression of IL-1alpha ... Inhibition of Erk in transgenic keratinocytes reduced basal IL-1alpha levels and the stimulation of IL-1alpha production by serum or phorbol ester, demonstrating that Erk could regulate IL-1alpha expression ... Inhibition of transactivation blocked basal and TPA or IL-1alpha induced Erk activation, but not IkappaBalpha degradation, and abolished increased IL-1alpha production in transgenic cells
MacGillivray et al., J Biol Chem 2003 (MAP Kinase Signaling System) : IL-1 induced ERK activation is markedly diminished in fibroblasts deprived of focal adhesions whereas activation of p38 and JNK is unaffected ... Here we demonstrate that SHP-2, a protein tyrosine phosphatase present in focal adhesions, modulates IL-1 induced ERK activation and the transient actin stress fiber disorganization that occurs following IL-1 treatment in human gingival fibroblasts ... Blocking anti-SHP-2 antibodies, electoporated into the cytosol of fibroblasts, inhibited IL-1 induced ERK activation, actin filament assembly, and cell contraction, indicating a role for SHP-2 in these processes ... In summary, our data indicate that SHP-2, a focal adhesion associated protein, participates in IL-1 induced ERK activation likely via an adaptor function
Garat et al., Cytokine 2003 : IL-1 activated all three mitogen activated protein ( MAP ) kinase family members : p38 MAP kinase, extracellular regulated kinases (ERK) , and c-Jun amino-terminal kinases (JNK)
Wang et al., FASEB J 2003 (Calcium Signaling) : IL-1 induced release of Ca2+ from internal stores is dependent on cell-matrix interactions and regulates ERK activation ... We conducted studies to elucidate which steps of cellular Ca2+ handling are affected by focal adhesions and by which mechanisms focal adhesions modulate IL-1 induced Ca2+ signals and ERK activation in human gingival fibroblasts ... Focal adhesions were also required for Ca2+ entry through store operated channels and for IL-1 induced ERK activation
Amin et al., Int J Oncol 2003 : Finally, IL-1beta induced proliferation of Balb 3T3 cells and inhibition of Erk and Akt signalings or their upstream signaling molecules, Src kinase and PKC by their inhibitors strongly inhibited IL-1beta dependent cell proliferation
Huang et al., Nat Immunol 2004 : Furthermore, MEKK3 is crucial for IL-1- and LPS induced activation of NF-kappaB and JNK-p38 but not ERK , indicating that MAPKs are differentially activated during IL-1R-TLR4 signaling
Qian et al., Biol Reprod 2004 (MAP Kinase Signaling System) : These data indicate that, in normal human cytotrophoblast cells, IL-1 beta induces HIF- 1 alpha mediated VEGF secretion and that IL-1 beta stimulated ERK1/2 activation may be involved in this process
Khan et al., J Biol Chem 2004 : Our functional studies show IL-1RAPL can activate JNK but not the ERK or the p38 MAP kinases, whereas its close homolog, TIGIRR, can not activate JNK
Wang et al., J Biol Chem 2005 : Because the non-receptor tyrosine phosphatase Src homology 2 domain containing protein tyrosine phosphatase-2 ( SHP-2 ) is enriched in focal adhesions and IL-1 induced ERK activation requires increased Ca ( 2+ ), we determined whether SHP-2 modulates IL-1 induced Ca ( 2+ ) signaling ... In SHP-2-deficient fibroblasts, IL-1 induced Ca ( 2+ ) signaling and ERK activation were markedly diminished compared with cells expressing SHP-2 ... Immunoprecipitation and immunostaining showed that SHP-2, the endoplasmic reticulum-specific protein calnexin, and PLCgamma1 were associated with focal adhesions ; however, these associations and IL-1 induced ERK activation dissipated after cells were plated on non-integrin substrates
Wang et al., FASEB J 2005 : Mitochondrial function is a critical determinant of IL-1 induced ERK activation ... Inhibition of cellular energetics by selective depolarization of mitochondria blocked Ca2+ uptake and almost completely abolished IL-1 induced cytosolic Ca2+ signals and ERK activation
Dardik et al., J Vasc Surg 2005 : Inhibition of PDGF-BB or IL-1alpha inhibited SMC chemotaxis and ERK1/2 phosphorylation
Fukushima et al., Bone 2005 : IL-1alpha activated ERK phosphorylation and PD98059 greatly inhibited both COX-2 mRNA expression and PGE ( 2 ) production induced by IL-1alpha in PDL cells
Petersen et al., Cytokine 2005 (MAP Kinase Signaling System) : Western blotting revealed that IL-1alpha activated p38 MAPK and JNK/SAPK, but not ERK , in Sertoli cells from 8- or 9-day-old rat
Rodríguez et al., Cell Signal 2006 : Most important, IL-1 induced ERK1/ERK2 activation is inhibited by PP1, a known inhibitor of Src tyrosine kinases, but this tyrosine kinase activity is not required for IL-1 to activate other MAP kinases such as p38 and JNK
Ginnan et al., Am J Physiol Cell Physiol 2006 : Taken together, we have outlined a novel transduction pathway implicating PKC-delta as a critical component of the IL-1 dependent activation of ERK in VSM cells
Sawai et al., BMC cell biology 2006 (Carcinoma, Pancreatic Ductal...) : IL-1alpha induced activation of Ras and downstream ERK can be inhibited by using inhibitory antibodies against alpha6 and beta1 integrin and uPAR, consistent with the inhibition of proliferation, adhesion and migration of pancreatic cancer cells
Ganesan et al., Blood 2006 (Inflammation) : Interestingly, whereas IL-6 production required activation of both PI3K and Ras/Erk pathways, IL-1beta production was dependent only on Ras/Erk activation, suggesting that SHIP may also regulate the Ras/Erk pathway in macrophages
Hayer et al., Arthritis Rheum 2007 (Arthritis...) : Early lesions were associated with up-regulation of interleukin-1 (IL-1) and IL-6 as well as activation of p38 MAPK and ERK
Alford et al., J Biol Chem 2007 (Inflammation) : IL-1 induced ERK activation appears to be independent of HSP27
Ogata et al., J Dent Res 2007 (MAP Kinase Signaling System...) : IL-1alpha ( PKC ), and PKC inhibitor staurosporine inhibited IL-1alpha induced phosphorylation of ERK1/2 , p38, and JNK, and decreased IL-1alpha induced COX-2 mRNA expression
Thiel et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid...) : PD184352 reduced IL-1alpha induced p-ERK levels in human RA synovial fibroblasts ... We observed IL-1alpha induced p-ERK in the synovial lining, subsynovial vasculature, and articular chondrocytes
Arakawa et al., Int Immunopharmacol 2008 (Melanoma) : ERK1/2 was constitutively activated in A375-6 cells, and IL-1 further augmented ERK activation
Totlandsdal et al., Toxicol In Vitro 2010 : Cellular release of IL-1alpha , IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 ( PD98069 ), p38 ( SB202190 ) and JNK ( SP600125 ), whereas pyrrolidine dithiocarbamate ( PDTC ) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta
Ralay Ranaivo et al., Brain Res 2010 (MAP Kinase Signaling System) : Albumin activated ERK1/2 , p38 MAPK and JNK signaling pathways in astrocytes, and induced the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase, the NO metabolite nitrite, and the chemokine CX3CL1 while reducing the level of S100B
Arakawa et al., Biochem Biophys Res Commun 2010 (Melanoma) : IL-1 induced ERK1/2 activation up-regulates p21 ( Waf1/Cip1 ) protein by inhibition of degradation via ubiquitin independent pathway in human melanoma cells A375 ... These results suggest that IL-1 induced ERK1/2 activation leads to the up-regulation of p21 by inhibiting degradation via ubiquitin independent pathway in human melanoma cells A375
Litherland et al., J Biol Chem 2010 : STAT3 gene silencing or ERK pathway inhibition also resulted in loss of IL-1 + OSM stimulated c-fos and collagenase expression
Wang et al., J Biol Chem 2010 : Interactions between SHP-2 and PTPalpha, recruitment of SHP-2 to focal adhesions, IL-1 induced ERK activation, and MMP3 expression were all blocked by point mutations in the phosphatase domains of PTPalpha
Rautava et al., Neonatology 2011 : TGF-ß2 markedly inhibited IL-1ß induced phosphorylation of ERK , which was necessary for the cytokine response
Nakano et al., Eur J Pharmacol 2011 : IL-1ß increased ERK activity, which was not affected by docetaxel
Chen et al., Neurochem Int 2011 : Pharmacological studies revealed that the integrity of lipid raft and the activation of Src, Ras, Raf, ERK , and NF-?B all contributed to JEV induced TNF-a and IL-1ß expression
Kim et al., Comp Immunol Microbiol Infect Dis 2011 (Staphylococcal Infections) : IL-1ß production was suppressed by inhibitors of lipid rafts, ERK , JNK, and p38 kinases
Wang et al., FASEB J 2011 : Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK ... In connective tissue cells, IL-1 induced ERK activation leading to matrix metalloproteinase (MMP)-3 expression is dependent on cooperative interactions between focal adhesions and the endoplasmic reticulum ( ER )
Miura et al., Infect Immun 2011 (Inflammation) : When the human leukemia cell line THP-1 was exposed to E. chaffeensis, significant upregulation of IL-8, IL-1ß , and TNF-a mRNA and extracellular regulated kinase 2 (ERK2) activation were detected
Sunaga et al., J Vet Med Sci 2012 (MAP Kinase Signaling System) : As a result, in the presence of PPS existence, IL-1ß induced phosphorylation of p38 and ERK were certainly inhibited, while JNK phosphorylation was not affected
Chao et al., Connect Tissue Res 2012 (Hypertrophy...) : It was also found that NF-?B inhibitor, but not ERK1/2 inhibitor, attenuated EDP dependent induction of IL-1a , IL-1ß, and IL-6 expression, indicating that NF-?B pathways are required for EDP induced IL-1a, IL-1ß, and IL-6 gene expression in human LF cells
Pang et al., Journal of neuroinflammation 2012 (MAP Kinase Signaling System) : Telmisartan did not modify IL-1ß induced ERK1/2 and p38 mitogen activated protein kinase ( MAPK ) phosphorylation or nuclear factor-?B activation but significantly decreased IL-1ß induced c-Jun N-terminal kinase (JNK) and c-Jun activation
Lin et al., Biomaterials 2012 : Blocking of ERK1/2 activation using a pharmacologic inhibitor reduced both elastin and IL-1ß gene expressions in 3D cultures ... Transient transfection of IL-1ß using siRNA, however, did not affect ERK1/2 activation but downregulated elastin gene expression suggesting that endogenous IL-1ß acts downstream from ERK1/2
Sylvester et al., Cell Physiol Biochem 2012 : MAP kinase kinase-specific inhibitor, U0126 inhibited IL-1 induced phosphorylation of ERK1/2 and down-regulated ADAMTS-4 expression and activity
Kim et al., Parasite Immunol 2013 : N. fowleri mediated IL-1ß and IL-6 expression requires ERK , JNK and p38 mitogen activated protein kinases ( MAPKs ) activation in astrocytes
Gotoh et al., Connect Tissue Res 2013 : ß-NAD ( + ) had no significant effect on the IL-1a induced phosphorylation of ERK1/2 , JNK, and p38 and also had no effect on the IL-1a induced degradation of I?Ba relative to the control, suggesting that inhibition by ß-NAD ( + ) was independent of the MAP kinase and the nuclear factor-?B signaling pathways
Wei et al., Spine (Phila Pa 1976) 2013 : ERK specific inhibitor U0126 significantly inhibited IL-1 induced ERK activation
Negoro et al., Scientific reports 2013 (Disease Models, Animal...) : In urothelial cells, IL-1ß stimulation increased Cx43 expression, dye coupling, and p38 MAPK phosphorylation but not ERK1/2 phosphorylation
Zhong et al., Int Immunopharmacol 2013 : Interestingly, vorinostat selectively inhibited IL-1ß induced p38 and ERK1/2 activation without affecting JNK activation
Rajshankar et al., PloS one 2013 : These data showed that the catalytic and adaptor functions of PTPa were required for IL-1ß induced focal adhesion formation, ERK activation and MMP-3 release
Lo et al., J Biol Chem 1998 : Cells in suspension and hence with no suitable substratum for focal adhesion formation also showed no ERK activation or enhanced c-fos expression in response to IL-1 ... Calcium depletion abolished IL-1 induced calcium uptake, ERK activation, and c-fos expression ... The focal adhesion dependence of IL-1 induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin