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TWIST1 — WNT3
Text-mined interactions from Literome
Watanabe et al., Anticancer Res 2004
(Breast Neoplasms) :
We reported
Twist expression was
regulated by
Wnt/beta-catenin signaling and that both Wnt-1 and Twist could contribute to mammary tumorigenesis
Luo et al., World J Gastroenterol 2008
(Neoplasm Invasiveness...) :
These results indicate that Twist promotes gastric cancer cell migration, invasion and metastasis, and
Twist may
play an important role in
Wnt/Tcf-4 signaling
Katoh et al., Curr Pharm Biotechnol 2011
:
Because FGF, Hedgehog, TGFß, and non-canonical
WNT signals synergistically
induce EMT regulators, such as Snail ( SNAI1 ), Slug ( SNAI2 ),
TWIST , and ZEB2 ( SIP1 ), tumor-stromal interaction at the invasion front aids cancer stem cells to acquire more malignant phenotype
Lai et al., Stem Cells 2011
:
In contrast,
Wnt3a induced expression of
Twist but not Twist2 or Spry4 and bone morphogenetic protein 2 (Bmp2) failed to alter expression of all three genes