Gene interactions and pathways from curated databases and text-mining

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EGFR — POU5F1

Text-mined interactions from Literome

Abhold et al., PloS one 2012 (Carcinoma, Squamous Cell...) : Activation of EGFR by the addition of EGF ligand or ectopic expression of EGFR in two established HNSCC cell lines ( UMSCC-22B and HN-1 ) resulted in the induction of CD44, BMI-1, Oct-4 , NANOG, CXCR4, and SDF-1
Yi et al., Otol Neurotol 2012 (Neuroma, Acoustic) : Activation of both EGFR and PDGFR resulted in increase in the induction of the expression of the stem cell genes Oct-4 and Nanog and marked increase in tumorsphere forming ability, but only PDGFR activation resulted in an increase in the side population in JS1 cells