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BLM — RAD51
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
RAD51
—
BLM
Wu et al., J Biol Chem 2001*
-
IRef Bind_translation Interaction:
RAD51
—
BLM
(coimmunoprecipitation)
Wu et al., J Biol Chem 2001*
-
IRef Bind_translation Interaction:
RAD51
—
BLM
(two hybrid)
Wu et al., J Biol Chem 2001*
-
IRef Bind_translation Interaction:
RAD51
—
BLM
(far western blotting)
Wu et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
BLM
—
RAD51
(physical association, affinity chromatography technology)
Srivastava et al., J Cell Sci 2009*
-
IRef Biogrid Interaction:
BLM
—
RAD51
(physical association, affinity chromatography technology)
Aygün et al., Proc Natl Acad Sci U S A 2008
-
IRef Biogrid Interaction:
BLM
—
RAD51
(physical association, affinity chromatography technology)
Wu et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
BLM
—
RAD51
(direct interaction, two hybrid)
Wu et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
BLM
—
RAD51
(direct interaction, far western blotting)
Wu et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
BLM
—
RAD51
(physical association, affinity chromatography technology)
Yang et al., Oncogene 2004*
-
MIPS CORUM MSH2/6-BLM-p53-RAD51 complex:
MSH2/6-BLM-p53-RAD51 complex complex (BLM-MSH2-MSH6-RAD51-TP53)
Yang et al., Oncogene 2004*
-
IRef Corum Interaction:
Complex of 11 proteins
(association, anti bait coimmunoprecipitation)
Yang et al., Oncogene 2004*
-
IRef Dip Interaction:
RAD51
—
BLM
(direct interaction, pull down)
Ouyang et al., PLoS Biol 2009*
-
IRef Dip Interaction:
RAD51
—
BLM
(direct interaction, anti tag coimmunoprecipitation)
Aygün et al., Proc Natl Acad Sci U S A 2008
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Yang et al., Oncogene 2004*
-
IRef Hprd Interaction:
RAD51
—
BLM
(in vitro)
Wu et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
RAD51
—
BLM
(in vivo)
Wu et al., J Biol Chem 2001*
-
IRef Ophid Interaction:
RAD51
—
BLM
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Sengupta et al., EMBO J 2003
(Bloom Syndrome) :
However,
BLM was
required for efficient localization of either wild-type or mutated ( Ser15Ala ) p53 to these foci and for physical association of p53 with
RAD51
Karmakar et al., Biochem Biophys Res Commun 2006
(Bloom Syndrome) :
To identify additional proteins required for the recruitment of BLM, we examined the recruitment of BLM in various mutants generated from chicken DT40 cells and found that the early accumulation of
BLM was not
dependent on the presence of ATM,
RAD17 , DNA-PKcs, NBS1, XRCC3, RAD52, RAD54, or WRN
Bugreev et al., J Biol Chem 2009
:
Surprisingly, we found that
BLM stimulates DNA strand exchange activity of
RAD51