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NOX4 — PTGS2

Text-mined interactions from Literome

Kobayashi et al., J Physiol Pharmacol 2001 (Stomach Ulcer) : In addition the expression of cyclooxygenase-2 and inducible nitric oxide synthase proteins increased PGE2 generation and NOx secretion in the ulcerated stomach were suppressed by FR167653
Barbieri et al., Cardiovasc Res 2003 (Arteriosclerosis) : Reactive oxygen species mediate cyclooxygenase-2 induction during monocyte to macrophage differentiation : critical role of NADPH oxidase
Saha et al., Cancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : An inhibitor of NADPH oxidase ( diphenyleneiodonium chloride ) blocked the PMA mediated induction of COX-2 expression
Shanmugam et al., Diabetes 2004 : In addition, an antioxidant and inhibitors of mitochondrial superoxide, NADPH oxidase , and glucose metabolism to glucosamine also blocked high glucose induced COX-2 expression to varying degrees
Bezdecny et al., Toxicol Appl Pharmacol 2007 : 2244-TCB mediated increases in superoxide anion were prevented by the NADPH oxidase inhibitor apocynin or the free radical scavenger 4-hydroxy TEMPO, but neither of these inhibitors affected the 2244-TCB induced changes in COX-2 mRNA levels or ( 3 ) H-AA release
Zhu et al., American journal of physiology. Renal physiology 2011 : In the presence of the COX-2 siRNA, the aldosterone induced increases in COX-2, NOX-2, and NOX-4 mRNAs and O ( 2 ) ( - ) production were completely blocked, suggesting that COX-2 causes increased expression of NOX-2 and NOX-4
Chen et al., Chem Res Toxicol 2012 (MAP Kinase Signaling System...) : This 2-ABP induced COX-2 expression was attenuated by ROS scavenger NAC and NADPH oxidase inhibitors apocynin and DPI
Feng et al., J Clin Invest 1995 : In addition, NADPH stimulated COX-2 expression, and an inhibitor of NADPH oxidase blocked COX-2 expression induced by TNF alpha