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CTNNB1 — TCHP

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 50 proteins (colocalization, proximity-dependent biotin identification)
• IRef Intact Interaction: Complex of 74 proteins (colocalization, proximity-dependent biotin identification)

Text-mined interactions from Literome

Wielenga et al., Am J Pathol 1999 (Adenoma...) : This suggests a link with disruption of APC tumor suppressor protein mediated regulation of beta-catenin/Tcf-4 signaling, which is crucial in initiating tumorigenesis
Webster et al., Genes Chromosomes Cancer 2000 (Breast Neoplasms...) : Two oncogenic mechanisms leading to beta-catenin stabilization are the loss of the APC tumor suppressor protein and the mutational activation of beta-catenin , such that the Axin/APC complex can no longer regulate it
Munemitsu et al., Proc Natl Acad Sci U S A 1995 (Colonic Neoplasms...) : Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
Bullions et al., Curr Opin Oncol 1998 (Neoplasms) : Binding to the adenomatous polyposis coli tumor suppressor protein can stimulate the degradation of beta-catenin , whereas signaling initiated by the extracellular Wnt-1 oncoprotein or selected mutations in beta-catenin itself results in the accumulation of higher levels of beta-catenin in the cytoplasm