Slaaby et al., Biochem J 2000
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Insulin induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade
Lee et al., J Biol Chem 1994
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Activation of phospholipase D induced by platelet derived growth factor is dependent upon the level of phospholipase C-gamma 1 ... PDGF stimulated PLD activation was 10-fold greater in 3T3-gamma 1 cells than in 3T3-C cells, indicating that PLD activation is dependent upon the level of PLC-gamma 1 ... Therefore, these results suggest that PDGF induced PLD activation may be a consequence of primary stimulation of PLC-gamma 1 and that PLD may play a role downstream from PLC-gamma 1 in PDGF triggered mitogenesis
Yeo et al., J Biol Chem 1994
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Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet derived growth factor ... In summary, these results indicate that activation of PLC gamma 1 and protein kinase C are necessary for the stimulation of PLD by PDGF and provide no evidence for alternative mechanisms