Gene interactions and pathways from curated databases and text-mining

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GNB2L1 — SRC

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Chang et al., Oncogene 2002 : Moreover, Src activity is necessary for both the tyrosine phosphorylation of RACK1 and the binding of RACK1 to Src 's SH2 domain that occur following PKC activation
Severino et al., J Cell Physiol 2004 : Furthermore, we provide evidence that E1A is able to antagonize the inhibitory effects of RACK1 on Src activity
Mamidipudi et al., FEBS Lett 2004 : Here, we show that RACK1 partially inhibits v-Src kinase activity, and the serum- and anchorage independent growth of v-Src transformed cells, but has no effect on focus formation
Miller et al., Oncogene 2004 : We found that the association of betaIIPKC and RACK1 is necessary for Src phosphorylation of RACK1 ... Src activity is required for tyrosine phosphorylation of RACK1 , and for RACK1 binding to Src, but not to betaIIPKC ... Endogenous Src kinase activity, as measured by phosphorylation of Sam68 ( a mitotic-specific Src substrate involved in cell cycle regulation and RNA splicing ) or p190RhoGAP ( a Src substrate and GTPase activating protein involved in actin reorganization ), increases with disruption of the Src-RACK1 complex, and decreases with enhanced complex formation ... RACK1 inhibits Src mediated p190RhoGAP signaling and actin cytoskeleton rearrangement
Mamidipudi et al., Mol Cell Biol 2004 (Neoplasms) : RACK1 regulates G1/S progression by suppressing Src kinase activity
Mamidipudi et al., Biochem Biophys Res Commun 2007 : Our results provide direct physiologic evidence that RACK1 regulates growth of NIH3T3 cells by suppressing the activity of Src and other cell cycle regulators in G1, and delaying entry into S phase
Doan et al., Exp Cell Res 2007 : RACK1 regulates Src activity and modulates paxillin dynamics during cell migration
Mamidipudi et al., Oncogene 2009 (Colonic Neoplasms) : Earlier we showed that RACK1 regulates growth of human colon cells by suppressing Src activity at G(1) and mitotic checkpoints
Liu et al., Neurol Res 2011 : At 7 days of final RACK1 administration, the effects of RACK1 on Src and p-ERK disappeared, and morphine place preference was restored
Swaminathan et al., Oncogene 2012 (Colonic Neoplasms...) : Previously we showed that Rack1 regulates the growth of colon cells by suppressing Src activity at G(1) and mitotic checkpoints, and in the intrinsic apoptotic and Akt cell survival pathways
Chang et al., Mol Cell Biol 1998 : Purified GST-RACK1 inhibited the in vitro kinase activity of Src in a concentration dependent manner ... GST-RACK1 ( 2 microM ) inhibited the activities of purified Src and Lck tyrosine kinases by 40 to 50 % but did not inhibit the activities of three serine/threonine kinases that we tested