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HDAC3 — SRC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kostyniuk et al., Oncogene 2002
:
Sodium butyrate and Trichostatin A strongly inhibited activity of each of these highly disparate SRC promoters, demonstrating
histone deacetylase inhibitors directly
repress SRC transcription
Dehm et al., Biochem Cell Biol 2004
(Neoplasms) :
Interestingly,
histone deacetylase (HDAC) inhibitors, agents with well documented anti-cancer activity,
repress SRC transcription in a wide variety of human cancer cell lines
Matteucci et al., Mol Cancer Res 2007
(Breast Neoplasms...) :
Thus, the CXCR4 induction by HGF in MCF-7 cells required NF-kappaB and Ets1 activations, downstream of phosphoinositide-3-kinase/Akt, whereas in HGF treated MDA-MB231 cells,
HDAC3 activation via
c-Src probably caused a reduction of transcription factor activities, such as that of NF-kappaB