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CA2 — EPHB2

Text-mined interactions from Literome

Wylie et al., Biochem J 1999 : We have examined the involvement of Ca2+ and protein kinase C ( PKC ) in ERK and JNK activation by the human G-protein coupled m2 and m3 muscarinic acetylcholine receptors ( mAChR ) expressed in Chinese hamster ovary ( CHO ) cells
Malaguti et al., FEBS Lett 1999 (Breast Neoplasms) : Transient Ca2+ dependent activation of ERK1 and ERK2 in cytotoxic responses induced by maitotoxin in breast cancer cells
Kimura et al., Cancer Res 1999 (Ovarian Neoplasms) : These results provide evidence that GnRHa stimulation of ERK activity may be mediated by Gbetagamma protein, not by PMA-sensitive protein kinase C nor extracellular Ca2+ in the Caov-3 human ovarian cancer cell line, suggesting that this cascade may play an important role in the antiproliferative effect of GnRHa
Li et al., Eur J Immunol 2000 (MAP Kinase Signaling System) : Thus, in normal human B cells, PI3K is upstream of the Ca2+ response while PI3K, Ca2+ release and protein kinase C are all required for ERK2 activation, and CD19 enhances the MAPK cascade at multiple levels, depending on the state of differentiation
Bobe et al., Am J Physiol Heart Circ Physiol 2003 (MAP Kinase Signaling System) : The investigation of the role of intracellular calcium concentration ( [ Ca2+ ] i ) and calcium mobilization with the Ca2+ chelator BAPTA and thapsigargin, respectively, indicated that thrombin- and thapsigargin induced phosphorylation of the EGFR but not ERK1/2 is dependent on an increase in [ Ca2+ ] i
Arnette et al., J Biol Chem 2003 : Ca2+ signaling from intracellular stores is also essential for ERK1/2 activation, because thapsigargin blocks ERK1/2 activation by glucose or GLP-1
Chen et al., J Exp Med 2003 : We show that in stimulated CD4+ T cells, TGF-beta inhibits phosphorylation and activation of the Tec kinase Itk, increase in intracellular Ca2+ levels, NFATc translocation, and activation of the mitogen activated protein kinase ERK that together regulate T cell differentiation
Rocic et al., Am J Physiol Cell Physiol 2003 (MAP Kinase Signaling System) : This effect was blocked by inhibitors of the ERK1/2 and p38 mitogen activated protein ( MAP ) kinase pathways, but not by PI3-kinase inhibition, and was dependent on PKC, intracellular Ca2+ , and tyrosine kinases
Wang et al., FASEB J 2003 (Calcium Signaling) : IL-1 induced release of Ca2+ from internal stores is dependent on cell-matrix interactions and regulates ERK activation
Kumar et al., FASEB J 2004 (Mechanotransduction, Cellular) : Removal of Ca2+ from the medium inhibited stretch induced ERK1/2 activation only in mdx muscle fibers but not in the normal fibers
Yano et al., Bone 2004 (Prostatic Neoplasms) : Using Western analysis, we observed that an increase in extracellular Ca2+ resulted in delayed activation of extracellular signal regulated kinase ( ERK ) in PC-3 cells
Azriel-Tamir et al., J Biol Chem 2004 : We demonstrate that Ca2+ release, mediated by the ZnR, induces phosphorylation of ERK1/2 , which is highly metal-specific, mediated by physiological concentrations of extracellular Zn2+ but not by Cd2+, Fe2+, Ni2+, or Mn2+
Johnson-Farley et al., J Neurochem 2005 (MAP Kinase Signaling System) : In contrast, 5-HT7A receptor mediated activation of Akt required increases in both [ cAMP ] and intracellular [ Ca2+ ], while activation of ERK was inhibited by Ca2+
Schmitt et al., J Neurosci 2005 : However, the mechanism by which Ca2+ activates ERK during LTP remains unknown
Wang et al., FASEB J 2005 : Here, we examined the impact of cell energetics and mitochondrial function on the regulation of IL-1 induced Ca2+ signals and ERK activation in human gingival fibroblasts, cells that are important targets for IL-1 induced destruction of extracellular matrix in inflamed connective tissues
Cho et al., Mol Cells 2005 (MAP Kinase Signaling System) : These findings indicate that ERK phosphorylation in response to glycated LDL involves the activation of PKC, PLC, and MEK, but is independent of intracellular Ca2+
Xie et al., Neuromolecular Med 2004 (Alzheimer Disease...) : Interestingly, acute application of Abeta or APP overexpression inhibits activity dependent regulation of several protein kinase pathways that require Ca2+ influx via NMDA receptors for activation, including Ca2+/calmodulin dependent protein kinase II, protein kinase A, and extracellular regulated kinases (Erk)
Norum et al., FEBS J 2005 : Therefore, both cAMP and Ca2+ may contribute to the Ras dependent ERK1/2 activation after 5-HT7 receptor stimulation, through activation of a guanine nucleotide exchange factor with activity towards Ras
Roberson et al., Mol Endocrinol 2005 : In the present studies, we examined the hypothesis that calmodulin (Cam) plays a fundamental role in mediating the effects of Ca2+ on ERK activation
Krysan et al., Cancer Res 2005 (Carcinoma, Non-Small-Cell Lung...) : Selective inhibition of EP receptors revealed the possible involvement of Ca2+ dependent signaling in PGE2 mediated activation of Erk
Barlow et al., Am J Respir Cell Mol Biol 2006 : Oxidant stress mediated regulation of extracellular signal regulated kinases ( ERK1/2 ) is linked to pathologic outcomes in lung epithelium, yet a role for Ca2+ and Ca2+/cAMP-response element binding protein ( CREB ) in ERK1/2 signaling has not been defined ... In this study, we tested the hypotheses that oxidants induce Ca2+ mediated phosphorylation of ERK and CREB, and that CREB is required for oxidant induced proliferation and apoptosis
Yamaguchi et al., J Am Soc Nephrol 2006 (Polycystic Kidney Diseases...) : Elevation of intracellular Ca2+ levels in ADPKD cells increased Akt activity and blocked cAMP dependent B-Raf and ERK activation
Raines et al., Biochem J 2006 : Previous studies from our laboratory have demonstrated that nNOS production of NO* blocks Ca2+-ionophore induced activation of ERK1/2 ( extracellular-signal regulated kinase 1/2 ) of the mitogen activated protein kinases through a mechanism involving Ras G-proteins and Raf-1 kinase ... Herein we describe a mechanism by which NO* blocks Ca2+ mediated ERK1/2 activity through direct modification of H-Ras ... Ca2+ mediated ERK1/2 activation in NO* producing cells could be restored by exogenous expression of constitutively active mitogen activated protein kinase kinase 1
Pham et al., J Cell Biochem 2006 : Activation of PKC by PDB resulted in the activation of ERK1/2, JNK, and CREB whereas activation of Ca2+ signaling by TG resulted in the delayed activation of ERK1/2
Lee et al., Biochem J 2007 : In the present study, we examined the effects of L-amino acids on Ca2+o stimulated ERK1/2 phosphorylation as determined by Western blotting and a newly developed quantitative assay ( SureFire ) ... L-Amino acids induced a small, but significant, enhancement of Ca2+o stimulated ERK1/2 ... L-Phenylalanine normalized the EC50 for Ca2+o stimulated Ca2+i mobilization from approx. 12 mM to 5.0 mM and ERK1/2 phosphorylation from approx. 4.6 mM to 2.6 mM
Massa et al., Ann N Y Acad Sci 2006 (Adenoma...) : We report that the inhibition of [ Ca2+ ] i increase or the blockade of BKCa channel activity did not affect ERK1/2 activation by SDF-1 ; Pyk2 activation was purely Ca2+ dependent , not involving ERK1/2 or BKCa channels ; and BKCa channel activity was antagonized by Pyk2 but not by ERK1/2 inhibitors
Wakamatsu et al., J Biol Chem 2007 : Moreover, Ca2+ induced activation of ERK through Rap1 and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; in turn, the inhibition of ERK activation reduced the amount of loricrin in wild-type keratinocytes
Kassel et al., J Pharmacol Exp Ther 2008 : The direct Ca2+- and phospholipid dependent protein kinase ( PKC ) activator phorbol-12-myristate-13-acetate stimulated ERK1/2 phosphorylation and decreased EGFR binding at both 15 min and 18 h
Lin et al., Am J Physiol Cell Physiol 2008 : Depletion of intracellular Ca2+ ( [ Ca2+ ] i by EGTA did not affect ERK activation by either agent
Zhao et al., J Neurosci Res 2008 (Brain Ischemia...) : Protein phosphatase 2A-negative regulation of the protective signaling pathway of Ca2+/CaM dependent ERK activation in cerebral ischemia
Mariggiò et al., Peptides 2008 (Calcium Signaling) : IgIII ( 270-280 ) -fragment-like H2N-DDSDEEN-COOH peptide modulates N-CAM expression via Ca2+ dependent ERK signaling during `` in vitro neurogenesis ''
Mayer et al., Endocrinology 2008 : The signaling pathway requires elevated cytosolic Ca2+ levels and activation of ERK and c-Jun N-terminal protein kinase
Rössler et al., BMC molecular biology 2009 : The signaling cascade connecting thrombin stimulation with Egr-1 gene expression required elevated levels of cytosolic Ca2+ , the activation of diacylgycerol dependent protein kinase C isoenzymes, and the activation of extracellular signal regulated protein kinase ( ERK ) ... This study shows that stimulus-transcription coupling in thrombin treated lung fibroblasts relies on the elevation of the intracellular Ca2+-concentration and the activation of PKC and ERK
Dougherty et al., Mol Cell 2009 (Calcium Signaling...) : Strikingly, we find that the protein phosphatase calcineurin selectively interacts with KSR2 and that KSR2 uniquely contributes to Ca2+ mediated ERK signaling ... Moreover, we find that depletion of endogenous KSR2 impairs Ca2+ mediated ERK activation and ERK dependent signaling responses in INS1 pancreatic beta-cells and NG108 neuroblastoma cells
Wannatung et al., Br J Haematol 2009 (MAP Kinase Signaling System...) : Modulation of either cAMP or Ca2+ or direct inhibition of MAPK/ERK kinase (MEK) reduced basal levels of ERK1/2 phosphorylation, as well as significantly reducing the level of erythroid expansion
Zhang et al., Can J Physiol Pharmacol 2010 (Calcium Signaling...) : Interestingly, endothelial nitric oxide synthase (eNOS) promotes TNF-alpha expression by enhancing p38 MAPK activation, whereas neuronal NOS (nNOS) inhibits TNF-alpha production by reducing Ca2+ dependent ERK1/2 activity
Dreses-Werringloer et al., J Cell Sci 2013 : CALHM1 controls the Ca2+ dependent MEK, ERK , RSK and MSK signaling cascade in neurons
Levi et al., Mol Endocrinol 1998 : Signaling by the G protein coupled receptor GnRH was shown to include elevation of Ca2+ and activation of phospholipases, protein kinase C ( PKC ) and extra-cellular signal regulated kinase ( ERK )
Ikeda et al., Biochem Biophys Res Commun 1998 : The aim of this study was to investigate the effect of Ca2+ on the activation of ERK1/2
Murasawa et al., Hypertension 1998 : These findings demonstrate that in cardiac fibroblasts, Ang II induced Ras/ERK activation is dominantly regulated by Gq-coupled Ca2+/calmodulin signaling and that Pyk2 plays an important role in the signal transmission for efficient activation of the Ang II induced Ras/ERK pathway
Impey et al., Neuron 1998 (Calcium Signaling) : The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB ... Interestingly, the Ca2+ induced nuclear translocation of ERK and Rsk2 to the nucleus requires protein kinase A (PKA) activation