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SHC1 — TYR

Text-mined interactions from Literome

Itoh et al., J Allergy Clin Immunol 1999 : Adding back each tyrosine to Fall revealed that ( 1 ) Tyr577 was necessary and sufficient for Shc phosphorylation ; ( 2 ) Tyr577, Tyr612, and Tyr695 were involved in activation of SHP-2, the Raf/ERK cascade, and c-fos transcription ; and ( 3 ) all tyrosines, but particularly Tyr612, Tyr695, Tyr750, and Tyr806, facilitated STAT5 activation
He et al., J Biol Chem 1995 : We confirm that Tyr-960 within the NPEY motif of the IR is essential for both IRS-1 and SHC interaction and that Asn-957 and Pro-958 are essential for IRS-1 interaction and important but not critical for SHC interaction
Itoh et al., J Biol Chem 1996 : When we analyzed signaling molecules functioning downstream of the beta-c we found that Tyr577 is essential for Shc phosphorylation, while tyrosine phosphorylation of PTP1D was mediated through Tyr577 as well as through other site ( s )