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AGTR1 — EPHB2

Text-mined interactions from Literome

Haendeler et al., Circ Res 2000 : Activation of ERK1/ERK2 by AT1Rwt was independent of Ca ( 2+ ), whereas the low level of ERK1/ERK2 activation by AT1R ( Del221/222 ) was completely Ca ( 2+ ) dependent
Mondorf et al., FEBS Lett 2000 : Ang II induced activation of ERK1/2 via the AT(1) receptor, and this response was blocked by the PDGFR-selective tyrosine kinase inhibitor AG1295, but not by AG1478, an EGFR-selective tyrosine kinase inhibitor, indicating participation of the PDGFR, but not of the EGFR in Ang II-induced ERK1/2 activation
Goetze et al., J Cardiovasc Pharmacol 2000 : TRO at I and 10 microM had no significant effect on insulin stimulated ERK1/2 activity
Shah et al., Mol Pharmacol 2002 : Agonist activation of endogenous angiotensin II (Ang II) AT(1) receptors expressed in hepatic C9 cells markedly stimulated inositol phosphate production, phosphorylation of the proline-rich tyrosine kinase PyK-2, and ERK activation
Takahashi et al., Eur J Clin Invest 2004 (Cardiomegaly...) : These data suggest that PKC and ERK1/2 are activated by an angiotensin II receptor mediated pathway and might play an important role in the progression of cardiac hypertrophy in renal failure
Shah et al., Mol Endocrinol 2004 : Although the Tyr319 residue of the AT1-R has been proposed to be an essential regulator of EGF-R transactivation, stimulation of wild-type and mutant ( Y319F ) AT1-R expressed in COS-7 cells caused EGF-R transactivation and subsequent ERK1/2 phosphorylation through release of HB-EGF in a Src dependent manner
Ahn et al., J Biol Chem 2004 : Differential kinetic and spatial patterns of beta-arrestin and G protein mediated ERK activation by the angiotensin II receptor
Filipeanu et al., J Biol Chem 2004 : Consistent with their effects on AT1R export, Rab1WT and Rab1N124I differentially modified the AT1R mediated activation of ERK1/2 and its upstream kinase MEK1
Cloëz-Tayarani et al., Life Sci 2004 : Our results showed an increase in ERK activation by 5-HT with a peak effect at 30 min and maximal stimulation with 5-HT at 1microM
Saito et al., Toxicology 2005 : NNN at 1 mM induced ERK1/2 phosphorylation, but reduced p38 phosphorylation ( P < 0.05, P < 0.01, respectively ) in the MEE
Olivares-Reyes et al., Mol Pharmacol 2005 : The dependence of these responses on caveolin was indicated by the finding that cholesterol depletion of C9 cells abolished Ang II-induced inositol phosphate production, activation of Akt/PKB and ERK1/2 , and AT(1)-R internalization
Liu et al., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006 (MAP Kinase Signaling System) : Ang II at 1 x 10 ( -7 ) mol/L or TGF-beta at 10.0 ng/ml significantly increased ERK phosphorylation of fibroblasts after stimulation ( P < 0.01 )
Yu et al., J Cell Biochem 2007 : Activation of ERK , JNK, Akt, and G-protein coupled signaling by hybrid angiotensin II AT1/bradykinin B2 receptors expressed in HEK-293 cells
Aplin et al., Basic Clin Pharmacol Toxicol 2007 : The angiotensin II (AngII) type 1 receptor ( AT(1)R ) has been shown to activate extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) through G proteins or G protein-independently through beta-arrestin2 in cellular expression systems ... To examine if AT(1)R activates ERK1/2 by G protein independent mechanisms in the heart, we used the [ Sar ( 1 ), Ile ( 4 ), Ile ( 8 ) ] -AngII ( [ SII ] AngII ) analogue in native preparations of cardiac myocytes and beating hearts
Lee et al., J Biol Chem 2008 (MAP Kinase Signaling System) : In contrast, only beta-arrestin2 supported protein kinase C-independent ERK1/2 activation by both the AT1a and DRY/AAY receptors
Landau et al., J Endocrinol 2008 (Body Weight...) : Cardiac angiotensin-1 (AT1) receptor protein levels were unchanged but the levels of phosphorylated ( p ) ERK and Jun-NH ( 2 ) -protein kinase ( JNK ) were increased in D and DS
Dong et al., Cell Signal 2008 : The cell-surface expression of alpha(2B)-AR, beta ( 2 ) -AR and AT1R , and receptor mediated ERK1/2 activation were significantly attenuated by the GTP bound mutant Sar1H79G, suggesting that export from the ER of these receptors is mediated through the Sar1 dependent COPII coated vesicles
Hosojima et al., Endocrinology 2009 : Insulin competed with the AT(1A)R mediated ERK activation and decrease in megalin expression ... Collectively the AT(1A)R mediated ERK signaling is involved in suppressing megalin expression in the OK cell line, and insulin competes with this pathway
Zhao et al., Mol Cell Biochem 2009 : The AT1 receptor was involved in Ang II-induced ERK5 activity
Yu et al., Chem Biol Drug Des 2010 : In contrast, the AT1 IC2 peptide had no effect on AngII/AT1 receptor activation of ERK
Li et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : Furthermore, the enhanced phosphorylation of ERK1/2 in VSMC from SHR was also attenuated by AT(1) , ET ( A ), ET ( B ), c-Src, and EGF-R inhibitors
Ozawa et al., Journal of ophthalmology 2011 : In diabetic retinopathy, angiotensin II type 1 receptor (AT1R) signaling activates ERK in the inner layers of the retina, causing UPS mediated excessive degradation of the synaptic vesicle protein, synaptophysin
Jiang et al., Neonatology 2012 (Disease Models, Animal...) : ERK phosphorylation might mediate angiotensin II type 1 receptor activation
Barauna et al., Biochem Biophys Res Commun 2013 : AT1R dependent SS-induced ERK activation involves Ca ( 2+ ) inflow and activation of Gaq since Ca ( 2+ ) chelator EGTA or Gaq-specific inhibitor YM-254890 decreased SS-induced ERK activation