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EPHB2 — STAT1

Text-mined interactions from Literome

Marra et al., Hepatology 1999 (Drug-Induced Liver Injury...) : In the presence of the ERK inhibitor, binding of the AP-1 complex and of STAT1 to the related regulatory elements was inhibited
Zhang et al., Carcinogenesis 2004 : In vitro kinase assays using the combined STAT1 proteins as substrates from immunoprecipitation and glutathione S-transferase pull down show that active ERK1 , JNK1, p38 kinase, MEK1 and MSK1 stimulated phosphorylation of STAT1 ( Ser727 ) indirectly through an unidentified factor or a downstream kinase
Nowroozi et al., Hum Mol Genet 2005 (Thanatophoric Dysplasia) : Using PC12 cell lines stably expressing inducible mutant receptors containing the TDII mutation, K650E, sustained activation of ERK1/2 and activation of STAT1 and STAT3, but not STAT5, is observed in the absence of ligand ... Silencing of STAT1 or 3 independently or in combination had no significant effect on ligand independent neurite outgrowth, ERK1/2 activation or p21 ( WAF1/CIP1 ) protein levels
Sharma-Walia et al., J Virol 2005 (Herpesviridae Infections...) : Several MAPK regulated host transcription factors such as c-Jun, STAT1alpha, MEF2, c-Myc, ATF-2 and c-Fos were induced early during infection, and ERK inhibition significantly blocked the c-Fos, c-Jun, c-Myc, and STAT1alpha activation in the infected cells
Soond et al., J Biol Chem 2008 : Moreover, silencing betaTRCP expression or pharmacological inhibition of ERK activity stabilized STAT1 expression
Benco et al., Reproduction 2009 : Overexpression of STAT1 reversed the effect of ghrelin on STAT1, PCNA, PGF, OXT ( from stimulatory to inhibitory ), BCL2, P ( 4 ) ( from inhibitory to stimulatory ), prevented ghrelin effect on caspase-3 and BAX, but did not affect ghrelin 's effect on MAPK/ERK1,2 expression
Zhao et al., Cell Mol Biol Incl Cyto Enzymol 2009 : U0126 induced up-regulation of ERK1/2 and down-regulation of phosphorylated ERK1/2 , increased STAT1 and STAT2 expression in a dose dependent manner, and activated STAT1/2 via their phosphorylation
Chung et al., J Pharmacol Sci 2010 (Inflammation) : In conclusion, this study proposes an anti-inflammatory mechanism of alpha-viniferin, down regulating STAT-1-inducible inflammatory genes via inhibiting ERK mediated STAT-1 activation in IFN-gamma stimulated macrophages
Li et al., J Immunol 2010 (Atherosclerosis) : In this study, we demonstrate that the IFN-gamma mediated phosphorylation of STAT1 on Ser ( 727 ), crucial for its maximal activity, was attenuated in human macrophages by pharmacological inhibition of ERK
Wang et al., Biochem Biophys Res Commun 2012 (Carcinoma, Hepatocellular...) : Moreover, sorafenib inhibited IFN-a induced oncogenic signaling of STAT3, AKT and ERK but not the activation of the tumor suppressor STAT1
Oguro et al., Eur J Cancer 2013 (Carcinoma, Renal Cell...) : Western blot analysis revealed that the tocilizumab enhanced the interferon induced phosphorylation of STAT1 and inhibited SOCS3 expression and the phosphorylation of both STAT3 and ERK
Fang et al., PloS one 2013 (Leukemia, Myeloid, Acute...) : MEK inhibitors PD98059 and U0216 not only inhibited the phosphorylation of STAT1, but also abrogated dasatinib induced myeloid differentiation, suggesting that MEK/ERK dependent phosphorylation of STAT1 might be indispensable for the differentiating effect of dasatinib in AML cells
Megeney et al., Dev Genet 1996 : In differentiated myotubes, LIF treatment resulted in the tyrosine phosphorylation of both STAT3 and STAT1, but ERK phosphorylation was not detectable, and bFGF treatment did not lead to STAT1 or STAT3 tyrosine phosphorylation