◀ Back to AKT2
AKT2 — ALK
Text-mined interactions from Literome
Bianco et al., Mol Cell Biol 2002
:
In contrast, CR-1 stimulation of mitogen activated protein kinase and
AKT in these cells is
independent of Nodal and
ALK4 , suggesting that CR-1 may modulate different signaling pathways to mediate its different functional roles
Osajima-Hakomori et al., Am J Pathol 2005
(Neuroblastoma) :
The suppression of activated
ALK in neuroblastoma cells by RNA interference significantly
reduced the phosphorylation of ShcC, mitogen activated protein kinases, and
Akt , inducing rapid apoptosis in the cells
Theodoraki et al., Exp Cell Res 2007
:
The mechanism underlying the
effect of
NPM-ALK on
Akt stability was probed by comparison of the turnover of the kinase after translation inhibition and geldanamycin treatment
Thakral et al., Pediatr Blood Cancer 2012
(Lymphoma, Large-Cell, Anaplastic) :
Pharmacologic inhibition of activated
ALK does not
reduce modest levels of activated
Akt as it does with the more abundant levels of activated STAT3 or STAT5