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AKT2 — KITLG

Text-mined interactions from Literome

Uddin et al., Biochem Biophys Res Commun 2000 : Our results demonstrate that PKB/Akt is activated by Epo and SCF , but not by IGF-1 in human primary erythroid progenitors
Endo et al., Exp Hematol 2001 : PP2 also inhibited SCF induced phosphorylation of Akt
Krystal et al., Mol Cancer Ther 2002 (Carcinoma, Small Cell...) : Both stem cell factor (SCF) and insulin-like growth factor (IGF)-I, components of prominent small cell lung cancer ( SCLC ) autocrine loops, as well as FCS, can potently activate phosphatidylinositol 3-kinase (PI3K)-Akt signaling, albeit with different kinetics ... SCF induced PI3K-Akt activation occurs rapidly but fades within 60 min ; IGF-I and FCS induced activation persists for at least 6 h. SCF and IGF-I mediated growth was potently inhibited by LY294002 in proportion to its ability to inhibit phosphatidylinositol 3-kinase (PI3K)-Akt signaling
Shivakrupa et al., Cell Signal 2005 : In this study, we used Lyn-deficient bone marrow mast cells ( BMMC ) to examine the contribution of this Src family member to tyrosine phosphorylation of Kit and SCF induced activation of Jnks, Akt , Stat3 and Erks
Reddy et al., Dev Biol 2005 : By using an in vitro oocytes culture system, we found that oocytes derived Akt and FKHRL1 are regulated by SCF
Arcaro et al., Cell Signal 2007 (Carcinoma, Small Cell) : Lipid raft integrity was essential for Src activation in response to stem cell factor (SCF) and raft disruption selectively inhibited activation of protein kinase B (PKB)/Akt in response to SCF stimulation
Quesada et al., Exp Neurol 2009 : MGF24 does not activate Akt signaling nor does Akt inhibition block MGF24 protection of SH-SY5Y cells
Li et al., Braz J Med Biol Res 2009 (Diabetes Mellitus, Experimental) : However, insulin or SCF could activate the phosphorylation of ERK1/2 and AKT in the diabetic cortex
Suyama et al., Oncol Rep 2010 (Lung Neoplasms...) : LY294002 and PD98059 inhibited SCF induced Akt and Erk activation in H209 cells, respectively ... If the SCF/c-kit contributes to Akt activation in vivo, the combination of STI571 and AMR may be effective against SCLC
Ciraolo et al., Mol Biol Cell 2010 (Azoospermia...) : In particular, p110beta is crucially needed in c-Kit mediated spermatogonial expansion, as c-Kit positive cells are lost in the adult testis and activation of Akt by SCF is blocked by a p110beta inhibitor
Shin et al., Exp Mol Med 2013 (Melanoma, Experimental) : Pretreatment of B16F10 cells with glyceollins dose-dependently inhibited SCF induced c-kit and Akt phosphorylation