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AKT2 — NRG2
Text-mined interactions from Literome
Goldshmit et al., J Biol Chem 2001
:
Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by
NRG in the presence of H ( 2 ) O ( 2 ), and protein kinase
B/AKT activation is
inhibited by LY294002
Lemmens et al., Circulation 2004
:
In cultured rat cardiomyocytes,
NRG-1beta enhanced nitrite production and
resulted in phosphorylation of endothelial NO synthase and the serine/threonine kinase
Akt
Hellyer et al., Am J Physiol Cell Physiol 2006
:
NRG also
increased phosphorylation of
Akt , a downstream effector of PI3K ... This
NRG induced increase in
Akt phosphorylation and protein synthesis was completely blocked by wortmannin, an inhibitor of PI3K but was unaffected by PD-98059, an inhibitor of MEK
Di Segni et al., J Mol Neurosci 2006
:
NRG induces prolonged activation of
PKB/Akt and Erk ... Taken together, these results indicate that in PC12-ErbB4 cells, the
NRG induced neuroprotective effect from MPP+ treatment, requires
PI3K/PKB/Akt and Ras/MapK signaling networks
Kéri et al., Neurochem Int 2009
:
In conclusion,
NRG1 induced
AKT phosphorylation is decreased in schizophrenia but not in other psychotic disorders
Kéri et al., Schizophr Bull 2011
:
There were 3 significant predictors of delusional ideas : decreased habituation,
NRG1 induced
AKT phosphorylation, and anxiety ... These results suggest that decreased habituation of arousal,
NRG1 induced
AKT phosphorylation, and anxiety are related to delusional ideation in the general population
Schmukler et al., PloS one 2012
(MAP Kinase Signaling System...) :
We also demonstrated that NRG- induced autophagy is independent of mammalian target of rapamycin (mTOR) inhibition since
NRG induces
Akt and S6K activation
Bernard et al., J Biol Chem 2012
(Disease Models, Animal...) :
Furthermore, in contrast to related ligands,
NRG4 enhanced cell survival but not proliferation or migration, and
stimulated phosphorylation of the anti-apoptotic mediator
Akt but not ERK MAPK