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PLA2G4A — PLD2

Text-mined interactions from Literome

Burke et al., Biochem Biophys Res Commun 1999 : In the present research, a role for phospholipase D ( PLD ) in the regulation of cPLA2 was shown based on a number of observations ... Further evidence for the involvement of PLD in the regulation of cPLA2 came from the observation that the stimulated production of diacylglycerol ( for which phosphatidic acid is a major source ) was greatly diminished in undifferentiated cells as compared to differentiated cells
Kim et al., J Immunol 1999 (Leukemia L1210...) : These results suggest a role for cPLA2 in the regulation of PLD2 activity in vivo ... This study is the first to demonstrate that PLD2 activity is up-regulated by Ca2+ influx and that cPLA2 may play a key role in the Ca2+ dependent regulation of PLD2 through generation of lysophosphatidylcholine
Kitatani et al., Biol Pharm Bull 2000 (Leukemia, Basophilic, Acute) : These results suggest that PA formed by the catalytic action of PLD is used as a substrate for cPLA2, thus PLD regulates cPLA2 activation in antigen stimulated RBL-2H3 cells
Parmentier et al., J Biol Chem 2001 : These data suggest that HETEs are the mediators of cPLA(2) dependent PLD activation by NE in VSMC ... We conclude that NE stimulates cPLA(2) dependent PLD(2) through lipoxygenase- and CYP4A derived HETEs via the Ras/ERK pathway by a mechanism involving tyrosine phosphorylation of PLD(2) in rabbit VSMC
Li et al., J Pharmacol Exp Ther 2005 : Furthermore, ETYA, cPLA(2) antisense, and cPLA(2) siRNA attenuated Ang II-elicited PLD activation ... These data indicate that Ang II-stimulated Akt activity is mediated by cPLA(2) dependent, p38 MAPK regulated PLD(2) activation and EGFR transactivation
Li et al., Am J Physiol Heart Circ Physiol 2005 (Carotid Artery Injuries) : In cultured vascular smooth muscle cells, ANG II activates Akt through cytosolic phospholipase A2 (cPLA2) dependent phospholipase D2 (PLD2)
Flamand et al., Br J Pharmacol 2006 : No alteration of phospholipase D ( PLD ) activity in fMLP activated PMN was observed with up to 10 microM pyrrophenone, suggesting that the cPLA2alpha inhibitor does not directly inhibit PLD