◀ Back to RAC1
ABI1 — RAC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database ErbB1 downstream signaling:
RAC1/GDP complex (RAC1)
→
SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1)
(modification, collaborate)
Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
Evidence: mutant phenotype, assay
-
NCI Pathway Database ErbB1 downstream signaling:
SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
Evidence: mutant phenotype, assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
RAC1/GDP complex (RAC1)
→
SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1)
(modification, collaborate)
Scita et al., Nature 1999, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
Evidence: mutant phenotype, assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Scita et al., Nature 1999, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
Evidence: mutant phenotype, assay
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
ABI1 (ABI1)
→
RAC1/GTP complex (RAC1)
(modification, collaborate)
Yamazaki et al., J Cell Sci 2007, Ryu et al., Mol Cell Biol 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
RAC1/GTP complex (RAC1)
→
ABI1/Sra1/Nap1 complex (ABI1-CYFIP2-NCKAP1)
(modification, activates)
Yamazaki et al., J Cell Sci 2007, Ryu et al., Mol Cell Biol 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of RAC1 activity:
RAC1/GDP complex (RAC1)
→
SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1)
(modification, collaborate)
Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004, Khanday et al., J Cell Biol 2006*
Evidence: assay
-
NCI Pathway Database Regulation of RAC1 activity:
SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004, Khanday et al., J Cell Biol 2006*
Evidence: assay
-
Reactome Reaction:
RAC1
→
ABI1
(reaction)
Suetsugu et al., J Cell Biol 2006, Miki et al., EMBO J 1998
-
Reactome Reaction:
RAC1
→
ABI1
(indirect_complex)
Leng et al., Proc Natl Acad Sci U S A 2005, Suetsugu et al., J Cell Biol 2006, Nakanishi et al., J Biochem 2007, Mendoza et al., Mol Cell 2011, Miki et al., EMBO J 1998
Text-mined interactions from Literome
Miki et al., Biochem Biophys Res Commun 2002
:
Interestingly, the intramolecular interaction is interrupted by the binding of WAVE2 and full-length IRSp53 associates with
Rac in the
presence of
WAVE2
Innocenti et al., J Cell Biol 2003
:
On growth factor stimulation, endogenous p85 and Abi1 consistently colocalize into membrane ruffles, and cells lacking p85 fail to support
Abi1 dependent
Rac activation
Oikawa et al., Nat Cell Biol 2004
:
Production of PtdIns ( 3,4,5 ) P ( 3 ) at the cell membrane by myristoylated phosphatidylinositol-3-OH kinase ( PI(3)K ) is sufficient to recruit
WAVE2 in the
presence of dominant negative
Rac and latrunculin, demonstrating that PtdIns ( 3,4,5 ) P ( 3 ) alone is able to recruit WAVE2
Suetsugu et al., J Cell Biol 2006
:
Purified
WAVE2 and purified WAVE2 complex were activated by IRSp53 in a
Rac dependent manner with PIP ( 3 ) -containing liposomes ... Therefore, IRSp53 optimizes the activity of the
WAVE2 complex in the
presence of activated
Rac and PIP ( 3 )
Harmon et al., PLoS Pathog 2010
(Astrocytoma...) :
Rac and the tyrosine kinase Abl then
activate the
Wave2 complex and promote Arp2/3 dependent actin polymerization