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IL6 — NA
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Gosset et al., Eur Respir J 1999
:
Since exogenous as well as endogenous thiols could be potent inhibitors of the production of cytokines, the
effects of
N-acetylcysteine (NAC) , glutathione ( GSH ) and modulated GSH synthesis on the production of tumour necrosis factor (TNF)-alpha,
interleukin (IL)-6 and IL-8 by human alveolar macrophages ( AMs ) was evaluated, as well as the potential role of intracellular GSH depletion on the effect of exogenous thiols ... Similarly,
NAC inhibited the production of TNF-alpha,
IL-6 and IL-8 in GSH depleted AMs obtained by BSO pretreatment
Jain et al., Diabetes Care 2003
(Diabetes Mellitus, Type 1...) :
N-acetylcysteine (NAC) prevented the
IL-6 secretion in acetoacetate treated U937 monocytes ... This study demonstrates that hyperketonemia increases
IL-6 levels in the blood of type 1 diabetic patients and that
NAC can
inhibit IL-6 secretion by U937 monocytic cells cultured in a ketotic medium
Song et al., J Pharmacol Exp Ther 2004
(Inflammation) :
Although EP and
NAC both
inhibited LPS induced nitric oxide and
interleukin (IL)-6 secretion, the former compound was considerably more potent than the latter
Frank et al., Thromb Haemost 2006
(Disease Models, Animal...) :
In addition,
NAC-pentasaccharide significantly
reduced IL-6 and MIP-2 expression and injury in the kidney I/R model
Geudens et al., J Heart Lung Transplant 2007
(Disease Models, Animal...) :
NAC also
resulted in significantly fewer macrophages, lymphocytes and neutrophils as well as IL-1 beta, keratinocyte cytokine ( KC ), monocyte chemoattractant protein (MCP)-1 and
IL-6 levels in BAL taken after reperfusion
Araki et al., J UOEH 2007
:
We also investigated the
effect of
NAC and PDTC on the production of
interleukein-6 (IL-6) , which is regulated transcriptionally by NF-kappa B in 3T3-L1 adipocytes
Zhang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010
:
To explore the
effect of
N-acetylcysteine ( NAC ) on the interleukin(IL)18 induced expression of tumor necrosis factor (TNF) alpha and
interleukin(IL) 6 in mouse vascular smooth muscle cells ( VSMC ) ...
NAC inhibited the mRNA expression and protein secretion of TNF-alpha and
IL-6 induced by IL-18 ( P > 0.01 )
Abdel Baki et al., PloS one 2010
(Brain Injuries) :
When dosed 3 hours before injury, MINO plus
NAC as single drugs
had no effect on
interleukin-1 formation ; together they synergistically lowered interleukin-1 levels
Masubuchi et al., Biol Pharm Bull 2011
(Drug-Induced Liver Injury) :
NAC and glutathione highly
stimulated the hepatic expression of cytokines, particularly
interleukin-6 , which might be involved in the alleviation of APAP hepatotoxicity
Beloosesky et al., The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2012
(Encephalitis...) :
NAC administered prior to and after LPS significantly
reduced fetal brain
IL-6 at E18 and E20 and IL-10 at E20
Lima Trajano et al., Inhal Toxicol 2011
(Acute Lung Injury...) :
NAC also
inhibited the transcription of NF?B,
IL-6 , TNF-a and COX2 usually induced by LPS
Ehsani et al., Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2012
:
To evaluate the
role of prophylactic ibuprofen and
N-acetylcysteine (NAC) on the levels of tumor necrosis factor alpha ( TNF- a ),
interleukin- 6(IL-6) and IL-17 and post-treatment pain level in chronic periapical lesions
Narimatsu et al., Invest Ophthalmol Vis Sci 2013
(Disease Models, Animal...) :
The levels of MCP-1, CCL11, and
IL-6 increased after light exposure were
suppressed by
NAC
Shibanuma et al., FEBS Lett 1994
:
We found that : ( i ) TNF alpha increased
IL-6 mRNA levels and this increase was
inhibited by
N-acetyl-L-cysteine (NAC) , a scavenger of reactive oxygen species
Muñoz et al., Blood 1996
:
Both PDTC and
NAC inhibited , in a dose dependent manner, the synthesis of
IL-6 , IL-8, and GM-CSF induced by tumor necrosis factor (TNF)-alpha or bacterial lipopolysaccharides (LPS) in human umbilical vein endothelial cells ( HUVEC )
Gukovsky et al., Am J Physiol 1998
(Pancreatitis) :
In particular,
NAC inhibited intrapancreatic trypsin activation and mRNA expression of cytokines
interleukin-6 and KC, which were dramatically induced by cerulein