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CNTN2 — IL6
Text-mined interactions from Literome
Li-Weber et al., Eur J Immunol 2001
:
We show that expression of
Tax stimulates
NF-IL6 binding to the PRE-I element and, consequently, enhances PRE-I mediated transcriptional activity
Sawada et al., FEBS Lett 1992
:
We demonstrated that
Tax expression
enhanced the production by glial cells of interleukin (IL)-1,
IL-6 , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and transforming growth factor ( TGF ) beta
Alefantis et al., J Biol Chem 2005
(Necrosis...) :
However, it is also known that extracellular
Tax induces the production and release of cytokines, such as tumor necrosis factor-alpha and
interleukin-6 , which have adverse effects on cells of the central nervous system
Horiuchi et al., Int J Cancer 2006
:
Human T-cell leukemia virus type-I
Tax induces expression of
interleukin-6 receptor (IL-6R) : Shedding of soluble IL-6R and activation of STAT3 signaling ... To examine
roles of
Tax in expression of the
IL-6R gene, the JPX-9 cell line was used, which is derived from Jurkat cell line expressing Tax cDNA ... Over-expression of
Tax enhanced
IL-6R expression but not in Tax mutant JPX-9/M cell line ... Consequently,
Tax mediated regulations of
IL-6R and sIL-6R observed in HTLV-I associated disorders may contribute to proliferation of HTLV-I infected T cells through activation of inducible STAT3, and ultimately affect malignant growth and transformation of T cells by HTLV-I
Yamashita et al., Blood 1994
:
To evaluate the involvement of the HTLV-1 encoded transacting factor ( Tax ) in this transactivation, we examined the
effect of transient cotransfection with the
Tax-expression plasmid, pMAX-Neo, on the transcription from the
IL-6 promoter by use of COS1 cells ... We further examined the
effect of
Tax on endogenous
IL-6 gene expression using the Jurkat clone, JPX-9, stably transfected with pMAX-Neo ... Our findings indicate an important
role of the
Tax protein in the expression of
IL-6 in cells infected with HTLV-1
Tsukada et al., Blood 1997
:
Based on the results obtained from the present study, we conclude that the IL1B promoter is a Tax-responsive sequence as a result of ability of
Tax to
induce binding of
NF-IL6 and Spi-1 to the IL1B promoter sequence through protein-protein interaction