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EZH2 — MYC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Salvatori et al., Genes & cancer 2011
:
Here, we show that in acute myeloid leukemia ( AML ),
c-Myc directly
controls the expression of
EZH2 , a component of the Polycomb repressive complex 2, and miR-26a
Koh et al., Oncotarget 2011
(Disease Models, Animal...) :
Here, we identify EZH2 as a target of the MYC oncogene in prostate cancer and show that
MYC coordinately
regulates EZH2 through transcriptional and post-transcriptional means ... Further, in human prostate cancer cells,
Myc negatively regulates miR-26a and miR-26b via direct binding to their parental Pol II gene promoters, and forced overexpression of miR-26a and miR-26b in prostate cancer cells
results in decreased
EZH2 levels and suppressed proliferation ... As a separate mechanism of EZH2 mRNA upregulation, we find that
Myc binds directly to and
activates the transcription of the
EZH2 promoter
Neri et al., Mol Cell Biol 2012
:
Myc regulates the transcription of the
PRC2 gene to control the expression of developmental genes in embryonic stem cells
Zhang et al., Cancer Cell 2012
(Lymphoma, B-Cell) :
MYC contributes to
EZH2 upregulation via repression of the EZH2 targeting miR-26a, and EZH2 induces MYC via inhibition of the MYC targeting miR-494 to create positive feedback