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CHUK — NOS2

Text-mined interactions from Literome

Rattan et al., Free Radic Biol Med 2003 : Rho A negatively regulates cytokine mediated inducible nitric oxide synthase expression in brain derived transformed cell lines : negative regulation of IKKalpha
Chen et al., Carcinogenesis 2005 : Furthermore, impairing nuclear factor-kappaB (NFkappaB) activation by either NEMO-BDBP, an NFkappaB specific inhibitor, or overexpression of DN-IkappaBalpha or IKK-KM markedly inhibited the expression of B [ a ] P-induced iNOS , suggesting that the NFkappaB pathway is also required for the induction of iNOS by B [ a ] P
Chen et al., Eur J Pharmacol 2005 : Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase , nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia
Koo et al., Immunopharmacol Immunotoxicol 2005 : Neuroprotective effect of Chuk-Me-Sun-Dan on NMDA- and AMPA evoked nitric oxide synthase activity in mouse brain
Pan et al., Biochem Pharmacol 2006 (Cocarcinogenesis...) : Taken together, these results show that acacetin down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NF kappa B by interfering with the activation PI3K/Akt/IKK and MAPK, suggesting that acacetin is a functionally novel agent capable of preventing inflammation associated tumorigenesis
Liang et al., J Pineal Res 2009 (Reperfusion Injury) : Survival, transaminases, histology, flow cytometry, inducible nitric oxide synthase (iNOS) expression, and activation of signal transduction pathways [ c-Jun N-terminal kinase (JNK), cJUN, IkappaB kinase alpha (IKKalpha) , proliferating cell nuclear antigen ( PCNA ), and Ki67 ] were assessed for hepatic injury, oxidative stress, and cell proliferation
Pan et al., J Agric Food Chem 2008 : Taken together, these results show that pterostilbene down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of PI3K/Akt/IKK and MAPK
Kumar et al., Carcinogenesis 2012 (Carcinoma, Squamous Cell...) : Single application of NX ( 1.0mg/mouse ) prior to 12-O-tetradecanoylphorbol 13-acetate ( TPA ) application significantly inhibited TPA induced skin edema, hyperplasia, thymidine incorporation and ornithine decarboxylase (ODC) activity ; expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) ; phosphorylation of extracellular signal regulated kinases ( ERK ) 1/2, p38 and c-jun N-terminal kinase ( JNK ) mitogen activated protein kinases ( MAPKs ) ; and activation of I kappa B kinase (IKK) , I?Ba and nuclear factor-kappa B ( NF-?B ) in mouse skin
Zheng et al., Exp Cell Res 2013 : Exposure to wortmannin abrogated IKK/I?B/NF-?B mediated iNOS expression, suggesting activation of such a signal pathway might be phosphoinositide-3-kinase (PI3K) dependent