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NOS2 — VEGFA
Text-mined interactions from Literome
Feng et al., Biochem Biophys Res Commun 1999
:
VEGF induces nuclear translocation of Flk-1/KDR, endothelial
nitric oxide synthase , and caveolin-1 in vascular endothelial cells
Kane et al., Br J Pharmacol 2001
:
The increased tissue survival associated with the capacity for iNOS expression may be related to
iNOS dependent enhancement of
VEGF levels and an ensuing angiogenic response
Jozkowicz et al., Cardiovasc Res 2001
:
Genetic augmentation of
nitric oxide synthase increases the vascular generation of
VEGF
Joussen et al., Am J Pathol 2002
(Diabetes Mellitus, Experimental...) :
Retinal
vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial
nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo
Ando et al., J Cell Physiol 2002
(Ischemia...) :
In mice with oxygen induced ischemic retinopathy, deficiency of eNOS, but not
iNOS or nNOS
caused a significant decrease in retinal neovascularization and decreased expression of
VEGF
Park et al., J Korean Med Sci 2002
(MAP Kinase Signaling System) :
Expression and
regulation of endothelial
nitric oxide synthase by
vascular endothelial growth factor in ECV 304 cells
Jin et al., Circ Res 2003
:
Ligand independent activation of
vascular endothelial growth factor receptor 2 by fluid shear stress
regulates activation of endothelial
nitric oxide synthase
Bauer et al., Proc Natl Acad Sci U S A 2005
:
Second, despite a lack of quantitative changes in organelle number, endothelial-specific expression of Cav-1 impairs endothelial
nitric oxide synthase activation, endothelial barrier function, and angiogenic
responses to exogenous
VEGF and tissue ischemia
Yu et al., Proc Natl Acad Sci U S A 2005
(Ischemia...) :
The genetic loss of endothelial derived
nitric oxide synthase ( eNOS ) in mice
impairs vascular endothelial growth factor ( VEGF ) and ischemia initiated blood flow recovery resulting in critical limb ischemia
Feliers et al., Kidney Int 2005
(MAP Kinase Signaling System) :
VEGF regulation of endothelial
nitric oxide synthase in glomerular endothelial cells
Tao et al., Clin Exp Dermatol 2006
(Melanoma, Experimental) :
These results indicate that
VEGF enhances the expression of
iNOS in A375 cells and results in an increase in NO formation, which may be important in the process of VEGF induced proliferation of A375 cells
Ahmed et al., Fetal Pediatr Pathol 2005
(Hydatidiform Mole) :
Endothelial
nitric oxide synthase is
induced by
vascular endothelial growth factor and has been implicated in the pathogenesis of preeclampsia and other physiologic conditions in the placenta
Xie et al., J Sex Med 2005
(Erectile Dysfunction...) :
VEGF signaling
leads to the phosphorylation of Akt and endothelial
nitric oxide synthase ( p-Akt and p-eNOS )
Bardal et al., Diabetologia 2006
(Diabetes Mellitus, Experimental) :
VEGF also
prevented the apparent paradoxical increased endothelial
nitric oxide synthase expression seen in untreated STZ rats
Camp et al., Clin Cancer Res 2006
(Neovascularization, Pathologic...) :
Roles of
nitric oxide synthase inhibition and
vascular endothelial growth factor receptor-2
inhibition on vascular morphology and function in an in vivo model of pancreatic cancer
Kilic et al., FASEB J 2006
(Brain Ischemia) :
Following 90-min episodes of middle cerebral artery occlusion,
VEGF increased phosphorylated ( but not total ) Akt and ERK-1/-2 and reduced phosphorylated mitogen activated protein kinase/p38 and c-Jun NH2-terminal kinase (JNK)-1/-2 levels, at the same time decreasing
inducible NO synthase expression in ischemic neurons
Bhandari et al., Proc Natl Acad Sci U S A 2006
(Asthma...) :
These studies demonstrate that
VEGF selectively
stimulates eNOS and
iNOS
Zeng et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2007
(Carcinoma, Squamous Cell...) :
To investigate the
effect of
inducible nitric oxide synthase (iNOS) on
vascular endothelial growth factor ( VEGF ) expression
González et al., Lab Invest 2007
(Birth Weight...) :
Amniotic fluid from preeclamptic women, but not from normal women, inhibited
vascular endothelial growth factor induced endothelial cell proliferation and
nitric oxide synthase activity in cultured endothelial cells, and these actions were reversed by antibodies able to neutralize the effects of vasoinhibins
He et al., Pathobiology 2007
(Anoxia...) :
Inducible
nitric oxide synthase mediates hypoxia induced hypoxia-inducible factor-1 alpha activation and
vascular endothelial growth factor expression in oxygen induced retinopathy
Chen et al., J Reconstr Microsurg 2009
(Ischemia) :
The purpose of this investigation was to elucidate the
regulation of
inducible nitric oxide synthase (iNOS) expression by
vascular endothelial growth factor ( VEGF ) in a muscle flap ischemia model in rats
Ferraro et al., Mol Ther 2009
:
The short-term increase in
VEGF was
sufficient to mediate an upregulation of endothelial
nitric oxide synthase , an angiogenic factor that increases vascular permeability
Olszewska-Pazdrak et al., Am J Physiol Cell Physiol 2009
(Anoxia...) :
Hypoxia attenuated
VEGF stimulated activation of endothelial
nitric oxide ( NO ) synthase ( eNOS ) ( approximately 72 % ) and reduced NO production in VEGF stimulated cells from 237 +/- 38.8 to 61.3 +/- 28.4 nmol/l
Lamers et al., J Cell Mol Med 2011
(Inflammation) :
Expression of
iNOS and production of nitric oxide was only
enhanced by combined treatment inducing a marked release of
VEGF
Wheat et al., Arterioscler Thromb Vasc Biol 2011
:
Exposure to acrolein blocked vascular endothelial growth factor ( VEGF ) /AMD3100 stimulated mobilization of Flk-1 ( + ) /Sca-1 ( + ) but not Sca-1 ( + ) -only cells and prevented
VEGF induced phosphorylation of Akt and endothelial
nitric oxide synthase in the aorta
Hou et al., Cardiovasc Res 2012
:
N-terminal domain of soluble epoxide hydrolase negatively regulates the
VEGF mediated
activation of endothelial
nitric oxide synthase
Lankhorst et al., J Hypertens 2013
(Hypertension...) :
As
VEGF increases the expression and the activity of
nitric oxide synthase in endothelial cells, a decrease in the bioavailability of nitric oxide has been proposed as a key mechanism leading to hypertension during angiogenesis inhibition
Yoshida et al., Circulation 2013
(Feminization...) :
In in vitro studies, siRNA mediated ablation of AR in vascular endothelial cells blunted
VEGF stimulated phosphorylation of Akt and endothelial
nitric oxide synthase
Kroll et al., Biochem Biophys Res Commun 1998
:
VEGF-A induces expression of eNOS and
iNOS in endothelial cells via VEGF receptor-2 ( KDR ) ... Using porcine aortic endothelial cells overexpressing either VEGF receptor-2 ( PAE/KDR cells ) or VEGF receptor-1 ( PAE/Flt-1 cells ), we have studied the regulation of
iNOS and eNOS expression in
response to
VEGF-A stimulation