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ATF3 — JUN
Pathways - manually collected, often from reviews:
-
NCI Pathway Database AP-1 transcription factor network:
JUN (JUN)
→
JUN/ATF3 complex (JUN-ATF3)
(modification, collaborate)
Hai et al., Proc Natl Acad Sci U S A 1991, Filén et al., J Immunol 2010*
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUN (JUN)
→
ATF3 (ATF3)
(modification, collaborate)
Hai et al., Proc Natl Acad Sci U S A 1991, Filén et al., J Immunol 2010*
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUN/ATF3 complex (JUN-ATF3)
→
ATF3 (ATF3)
(modification, collaborate)
Hai et al., Proc Natl Acad Sci U S A 1991, Filén et al., J Immunol 2010*
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
ATF3 (ATF3)
(transcription, activates)
Kool et al., Oncogene 2003*, Yuan et al., Mol Cell Biol 2009*, Chaveroux et al., Mol Cell Biol 2009*
Evidence: assay, reporter gene
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
ATF3
—
JUN
Newman et al., Science 2003
-
IRef Bind_translation Interaction:
ATF3
—
JUN
(array technology)
Newman et al., Science 2003
-
IRef Biogrid Interaction:
ATF3
—
JUN
(physical association, affinity chromatography technology)
Pearson et al., Brain Res Mol Brain Res 2003*
-
IRef Biogrid Interaction:
ATF3
—
JUN
(physical association, affinity chromatography technology)
Filén et al., J Immunol 2010*
-
IRef Biogrid Interaction:
ATF3
—
JUN
(physical association, affinity chromatography technology)
Chen et al., Mol Cell Biol 1996*
-
IRef Biogrid Interaction:
ATF3
—
JUN
(direct interaction, pull down)
Hai et al., Proc Natl Acad Sci U S A 1991
-
IRef Biogrid Interaction:
ATF3
—
JUN
(direct interaction, fluorescent resonance energy transfer)
Reinke et al., Science 2013
-
IRef Dip Interaction:
ATF3
—
JUN
(physical association, coimmunoprecipitation)
Hai et al., Proc Natl Acad Sci U S A 1991
-
IRef Hprd Interaction:
ATF3
—
JUN
(in vitro)
Pearson et al., Brain Res Mol Brain Res 2003*, Hagmeyer et al., Oncogene 1996*
-
IRef Hprd Interaction:
ATF3
—
JUN
(in vivo)
Pearson et al., Brain Res Mol Brain Res 2003*, Hagmeyer et al., Oncogene 1996*
-
IRef Intact Interaction:
ATF3
—
JUN
(physical association, coimmunoprecipitation)
Duyndam et al., Oncogene 1999*
-
IRef Ophid Interaction:
ATF3
—
JUN
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
ATF3
—
JUN
(aggregation, confirmational text mining)
Pearson et al., Brain Res Mol Brain Res 2003*
Text-mined interactions from Literome
Mao et al., J Immunol 2001
:
Furthermore, the bZip elements of the two promoters bind different transcription factors, as the GL epsilon promoter binds and is activated by
AP-1 , whereas the gamma1 promoter binds and is
activated by
activating transcription factor 2
Nobori et al., J Mol Cell Cardiol 2002
:
DOX rapidly activated JNK and
c-Jun and
induced ATF3 at both mRNA and protein level
Lindwall et al., Mol Cell Neurosci 2004
:
Peripheral severance of the vagus or the sciatic nerve resulted in a massive and rapid, but transient increase of the activated JNK ( p-JNK ) in neuronal nuclei, followed by
c-Jun phosphorylation and activating transcription factor-3
(ATF3) induction ... JNK inhibition by the selective JNK inhibitors SP600125 and ( D ) -JNKI1 did not affect neuronal survival in explanted or dissociated ganglia, but dramatically reduced axonal outgrowth,
c-Jun activation, and
ATF3 induction
Seijffers et al., Mol Cell Neurosci 2006
(Peripheral Nerve Injuries) :
ATF-3 overexpression did not
increase c-Jun expression
Lu et al., J Dermatol 2013
:
Importantly,
JUN may
regulate activating transcription factor 3 expression to involve cell proliferation process ; STAT1 and STAT3 can inhibit tissue inhibitor of metalloproteinases-3 expression to modulate the cell adhesion molecule pathway ; NF-?B and E2F1 can downregulate cyclin D1, but upregulate proliferating cell nuclear antigen expression to promote the cell cycle pathway
Suk et al., Anticancer Res 2013
(Adenocarcinoma...) :
The up-regulation of
ATF3 was
blocked by a
c-JUN N-terminal kinase (JNK) or p38 inhibitor
Hagmeyer et al., Oncogene 1996
:
Altered
AP-1/ATF complexes in adenovirus-E1 transformed cells
due to EIA dependent induction of
ATF3