Lin-Lee et al., Biochem Pharmacol 2001
(Colorectal Neoplasms) :
These results suggest that the effects of p53 on the induced expression of MRP1 and gamma-GCSh depend on the environment of the cell and/or nature of p53 mutations
Grzywacz et al., Cancer Res 2003
:
We previously found that the multidrug resistance protein (MRP) , MRP1, is overexpressed in advanced stage and grade human prostate cancer and is negatively regulated by p53 Hait et al., Trans Am Clin Climatol Assoc 2006
(Neoplasms) :
We also discovered that p53 could regulate the expression of multidrug resistance protein-1 (MRP1) , a member of the ABC family of transporters that mediates the sensitivity to vinca alkaloids and anthracyclines ... We went on to show that p53 regulated the expression of MRP1 and that this produced resistance to doxorubicin and vinblastine
Wang et al., Cancer Res 1998
:
Cotransfection of MRP promoter constructs with p53 expression plasmids in p53-null human H1299 and mouse ( 10 ) 1 cells demonstrated that the wild-type ( wt ) p53 markedly suppressed MRP promoter activity, whereas mutant p53 had little inhibitory effect