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BMP4 — WNT11

Text-mined interactions from Literome

McGrew et al., Mech Dev 1999 : The co-activation of Wnt signaling and concomitant inhibition of BMP signaling has previously been implicated in vertebrate neural patterning, as evidenced by the combinatorial induction of engrailed-2 and krox-20 in Xenopus
Baker et al., Genes Dev 1999 : Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development ... We show that Wnt8 , but not the BMP antagonist Noggin, can inhibit Bmp4 expression at early gastrula stages ... Therefore, we suggest that a cleavage-stage Wnt signal normally contributes to an early repression of Bmp4 on the dorsal side of the embryo and sensitizes the ectoderm to respond to neural inducing signals from the organizer
Liu et al., J Biol Chem 2006 : Expression of a mutant Smad1 protein, which can not be phosphorylated in response to BMP, eliminated the inhibitory effect of BMP on Wnt-inducedbeta-catenin accumulation and transcriptional activity
van Bezooijen et al., J Bone Miner Res 2007 : In contrast, sclerostin shared many characteristics with the Wnt antagonist dickkopf-1 in antagonizing BMP stimulated bone formation and BMP- and Wnt induced Wnt reporter construct activation
Im et al., Biochem Biophys Res Commun 2007 : The PRDC induced by Wnt/beta-catenin does not inhibit Wnt signaling, but does inhibit BMP-4 signaling
Patthey et al., PloS one 2008 : By using in vitro assays of neural crest and placodal cell differentiation, we now provide evidence that Wnt signals impose caudal character on neural plate border cells at the late gastrula stage, and that under these conditions, BMP signals induce neural crest instead of rostral placodal cells
Kami et al., PloS one 2008 : Furthermore, BMP2 inhibited Wnt/beta-catenin signaling that promoted CL6 cardiomyogenesis
Patthey et al., Development 2009 : Our results indicate, however, that at this stage BMP signals can induce neural plate border cells only when Wnt activity is blocked, and that the two signals in combination generate epidermal cells
Steventon et al., Development 2009 : By performing tissue recombination experiments and using specific inhibitors of different inductive signals, we show that the first inductive step requires Wnt activation and BMP inhibition , whereas the later maintenance step requires activation of both pathways
Friedman et al., J Biol Chem 2009 : Wnt11 overexpression in MC3T3E1 pre-osteoblasts increases beta-catenin accumulation and promotes bone morphogenetic protein ( BMP ) -induced expression of alkaline phosphatase and mineralization
Paige et al., PloS one 2010 : Using quantitative RT-PCR, we show that canonical Wnt ligand expression is induced by activin A/BMP4 treatment, and the extent of early Wnt ligand expression can predict the subsequent efficiency of cardiogenesis ... Finally, we show that Wnt/beta-catenin signaling is required for Smad1 activation by BMP4
Kamiya et al., Curr Mol Pharmacol 2012 (Bone Resorption) : We recently generated an osteoblast targeted deletion of BMP signaling using a Cre-loxP strategy and found that BMP signaling in osteoblasts can inhibit Wnt signaling through the Wnt inhibitors DKK1 and SOST
Kim et al., Biochem Biophys Res Commun 2012 (Wnt Signaling Pathway) : Taken together, our results demonstrated that HDAC activity plays a pivotal role in vertebrate heart tube formation by activating Wnt/ß-catenin signaling which induces bmp4 expression in AVC myocardial cells ... During vertebrate heart valve formation, Wnt/ß-catenin signaling induces BMP signals in atrioventricular canal ( AVC ) myocardial cells and underlying AVC endocardial cells then undergo endothelial-mesenchymal transdifferentiation ( EMT ) by receiving this BMP signals
Klaus et al., Proc Natl Acad Sci U S A 2012 (Wnt Signaling Pathway) : Using FACS enrichment of cardiac progenitors in RBPJ and RBPJ/Axin2 mutants, embryo cultures in the presence of the Bmp inhibitor Noggin, and by crossing a Bmp4 mutation into the RBPJ/Axin2 mutant background, we show that Wnt and Bmp4 signaling activate specific and nonoverlapping cardiac-specific genes in the cardiac progenitors : Nkx2-5, Isl1 and Baf60c are controlled by Wnt/ß-catenin , and Gata4, SRF, and Mef2c are controlled by Bmp signaling
Kuroda et al., Skeletal muscle 2013 : Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts
Hoppler et al., Mech Dev 1998 : Although BMP-2/-4 signaling regulates Wnt-8 expression, these genes do not function in a linear pathway because Wnt-8 overexpression can not compensate for an inhibition of BMP-2/-4 function, but rather BMP-4 overexpression rescues ventral gene expression in embryos with inhibited Wnt-8 function
Godin et al., Development 1998 : By contrast, BMP7 expression in the metanephric mesenchyme is dependent on proteoglycans and possibly Wnt signaling