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APP — NCSTN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: NCSTN — APP (affinity chromatography technology) Shah et al., Cell 2005*
• IRef Bind_translation Interaction: NCSTN — APP (coimmunoprecipitation) Shah et al., Cell 2005*
• IRef Biogrid Interaction: NCSTN — APP (physical association, affinity chromatography technology) Yu et al., Nature 2000*
• IRef Hprd Interaction: NCSTN — APP (in vivo) Yu et al., Nature 2000*

Text-mined interactions from Literome

Leissring et al., Proc Natl Acad Sci U S A 2002 (Calcium Signaling) : Gamma-secretase mediated cleavage of APP , like that of Notch, yields an intracellular fragment [ APP intracellular domain (AICD) ] that forms a transcriptively active complex
Li et al., J Biol Chem 2003 : These data demonstrate that Nicastrin is essential for the gamma-secretase cleavage of APP and Notch in mammalian cells and that Nicastrin has both positive and negative functions in the regulation of gamma-secretase activity
Kume et al., Int J Mol Med 2004 : Gamma-secretase cleavage results in the generation of the APP intracellular domain (AICD) , as well as Abeta
Ajmani et al., Mol Divers 2013 : Gamma secretase (GS) is an appealing drug target for Alzheimer disease and cancer because of its central role in the processing of amyloid precursor protein and the notch family of proteins