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ABCA1 — PI3
Text-mined interactions from Literome
Huwait et al., Cell Signal 2011
:
The expression of ApoE and
ABCA1 induced by synthetic or natural LXR ligands [ TO901317, GW3965, and 22- ( R ) -hydroxycholesterol ( 22- ( R ) -HC ), respectively ] was
attenuated by inhibitors of c-Jun N-terminal kinase (JNK) ( curcumin and SP600125 ) and
phosphoinositide 3-kinase (PI3K) ( LY294002 )
Liu et al., Biochim Biophys Acta 2012
(Diabetes Mellitus, Type 2...) :
Silencing
ABCA1 in McArdle rat hepatoma cells results in diminished assembly of large ( > 10nm ) nascent HDL particles,
diminished PI3 kinase activation, and increased secretion of large, TG-enriched VLDL1 particles