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APCS — TLR7

Text-mined interactions from Literome

Thatcher et al., J Invest Dermatol 2006 (Dermatitis, Contact) : To model for the effects of TLR7 activation on the UV effect on antigen-APCs , XS52 cell line was used to study this interaction in an in vitro model system
Salio et al., Proc Natl Acad Sci U S A 2007 : We report that activation of human APCs by Toll-like receptor ligands ( TLR-L ) modulates the lipid biosynthetic pathway, resulting in enhanced recognition of CD1d associated lipids by iNKT cells, as defined by IFN-gamma secretion
Anz et al., J Immunol 2010 : This effect is entirely dependent on TLR7 activation of APCs and subsequent IL-6 production
Jones et al., J Immunol 2010 : These studies suggest that some age associated immune defects may be overcome by targeted activation of APCs by TLR ligands