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TLR3 — TLR7
Text-mined interactions from Literome
Harii et al., Mol Endocrinol 2005
(Thyroiditis, Autoimmune...) :
We conclude that functional TLR3 are present on thyrocytes
; TLR3 downstream signals can be overexpressed by pathogen related stimuli ; overexpression can be reversed by phenylmethimazole to a significantly greater extent than MMI by inhibiting only the IFN regulatory factor-3/IFN-beta/signal transducers and activation of transcription arm of the TLR3 signal system ; and
TLR3 overexpression can
induce an innate immune response in thyrocytes, which may be important in the pathogenesis of Hashimoto 's thyroiditis and in the immune cell infiltrates
Li et al., Immunology 2006
(Keratitis, Herpetic) :
Coincident with the second phase of NF-kappaB activation in HSV-1 infected HCECs, the expression of
Toll-like receptor 7 (TLR7) was
induced , whereas the level of
TLR3 was greatly down-regulated
Sel et al., J Immunol 2007
(Asthma...) :
These data indicate that
TLR-3 or TLR-7
activation by viral
TLR ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 ... These data indicate that TLR-3 or
TLR-7 activation by viral
TLR ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10
Kwissa et al., Blood 2012
:
In the draining lymph nodes ( LNs ), consistent with the effects in blood, all
TLR-Ls induced expansion of CD14 ( + ) monocytes, but only
TLR7/8-L and TLR9-L expanded the activated CD14 ( + ) CD16 ( + ) cells
Raicevic et al., Tissue Eng Part A 2012
:
Inflammation was mimicked by a cytokine cocktail, and
TLR activation was
induced through
TLR3 and TLR4 ligation
Melkamu et al., Journal of cell communication and signaling 2013
:
These findings demonstrate that
TLR3 activation differentially
regulates TLR expression through autocrine signaling involving IL-6 secretion, IL-6Ra activation and subsequent phosphorylation of Stat3
Römmler et al., J Immunol 2013
:
Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888,
TLR7 induced TNF-a release and
TLR7- and TLR9 induced IL-12p40 release were significantly more impaired by G-modified INH-ODNs