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MAP2K1 — MYC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cheng et al., J Biol Chem 1999
:
Expression of
c-Myc in response to colony stimulating factor-1
requires mitogen activated protein kinase kinase-1
Lefevre et al., Oncogene 2003
(Choroid Neoplasms...) :
The inhibition of both Raf-1 and
MEK1/2 induced a decrease in
c-Myc production and downregulated c-Myc activity by preventing c-Myc phosphorylation in OCM-1 cells
Hattrup et al., Breast Cancer Res 2006
(Breast Neoplasms...) :
Additional changes were seen at the protein level, such as increased expression of
c-Myc , heightened phosphorylation of AKT, and decreased
activation of
MEK1/2 and ERK1/2
Aziz et al., Mol Cell Biol 1999
:
Activation of Raf, v-Src, and
MEK1 led to induced expression of
c-Myc and cyclin D1