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MYC — PLXNB2
Text-mined interactions from Literome
Fujioka et al., J Biol Chem 2001
(Leukemia...) :
We previously showed that
MM-1 bound to myc box II within the transactivation domain of c-Myc and
repressed the E-box dependent transcriptional activity of
c-Myc
Hagio et al., J Cell Biochem 2006
:
Furthermore, when repression activities of MM-1 isoforms toward c-Myc transcription activity were examined by reporter gene assays in HeLa cells,
MM-1alpha , MM-1gamma, and MM-1gamma, but not MM-1beta, were found to
repress transcription activity of
c-Myc , and the degrees of repression by MM-1gamma and MM-1delta were smaller than those by MM-1 and MM-1alpha
Yoshida et al., Exp Cell Res 2008
:
Since the c-myc gene is the target gene of the Wnt-beta-catenin pathway, these findings suggest that
MM-1 inhibits
c-Myc by a dual mechanism
Miyazawa et al., J Biol Chem 2011
:
We previously identified MM-1a/PFD5 as a novel c-Myc binding protein and found that
MM-1a suppresses transformation activity of
c-Myc
Mori et al., J Biol Chem 1998
:
Furthermore,
MM-1 repressed the activation of E-box dependent transcription by
c-Myc